Abstract
The commitment of a totipotent hematopoietic stem cell and its terminal differentiation into the different hematopoietic lineages are certainly controlled by switching on and off a number of genes and by controlling the level of transcription of these genes. Despite the large amount of information that has been accumulated on the role of growth factors and cytokines in haematopoiesis, the role of transcriptional factors that are implicated in the developmental program of haematopoietic cells is less understood. Within this process, the megakaryocytic and erythroid lineage have multiple features in common. Both cells express receptors for erythropoietin, which is one of the major regulatory factors of erythrocyte production (Fraser et al., 1989). Erythroid specific transactivating factors are also produced in megakaryocytes and this includes GATA1 (Martin et al., 1990, Romeo et al., 1990), and NFE6 (Colin et al., 1990). Finally, the existence of a bipotent erythro-megakaryocytic burst forming cell has been suggested by clonal assays, using chromosomal markers (McLeod et al., 1989). Thus, there is ample evidence to suggest that the erythroid and megakaryocyte lineage are genetically related.
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© 1993 Plenum Press, New York
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Marguerie, G., Uzan, G. (1993). Transcriptional Regulation of the αIIβ Integrin Gene. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_1
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_1
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