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The Role of Lactoferrin as an Anti-Inflammatory Molecule

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Lactoferrin

Part of the book series: Advances in, Experimental Medicine and Biology ((AEMB,volume 357))

Summary

The formation of hydroxyl radical via the iron catalyzed Haber-Weiss reaction has been implicated in phagocyte-mediated microbicidal activity and inflammatory tissue injury. The fact that neutrophils contain lactoferrin and mononuclear phagocytes have the capacity to acquire exogenous iron has suggested that iron bound to lactoferrin may influence the nature of free radical products generated by these cells. Over the years the iron-lactoferrin complex has been heralded as both a promoter and inhibitor of hydroxyl radical formation. This manuscript is intended to provide an overview of work performed to date related to this controversy and to present results of a number of preliminary studies which shed further light on the role of lactoferrin in inflammation.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa, SW54, GH, Iowa City, IA, 52242, USA

    Bradley E. Britigan

  2. Research Service and Department of Internal Medicine VA Medical Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA

    Bradley E. Britigan

  3. Departments of Medicine and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    Jonathan S. Serody & Myron S. Cohen

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  2. Jonathan S. Serody
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  3. Myron S. Cohen
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Editors and Affiliations

  1. University of California, Davis, Davis, California, USA

    T. William Hutchens  & Bo Lönnerdal  & 

  2. Massey University, Palmerston North, New Zealand

    Sylvia V. Rumball

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© 1994 Springer Science+Business Media New York

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Britigan, B.E., Serody, J.S., Cohen, M.S. (1994). The Role of Lactoferrin as an Anti-Inflammatory Molecule. In: Hutchens, T.W., Rumball, S.V., Lönnerdal, B. (eds) Lactoferrin. Advances in, Experimental Medicine and Biology, vol 357. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2548-6_14

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  • DOI: https://doi.org/10.1007/978-1-4615-2548-6_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6087-2

  • Online ISBN: 978-1-4615-2548-6

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