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The Molecular Biology of Blood Groups: Relevance to the Study of Erythroid Maturation and the Clinical Management of Haemolytic Disease of the Newborn

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Hereditary Diseases and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 30))

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Abstract

In the past few years rapid advances have been made in our understanding of the molecular background of human blood group antigens. There are 23 different blood group systems found on human red cells. Two of these systems (CH/RG, LE) are not intrinsic to the red cell but acquired from plasma. Four systems (ABO, H, P, LE) are defined by carbohydrate structures and cDNAs corresponding to the glycosyl transferase responsible for ABO, H and LE antigens have been cloned and sequenced (reviewed in Lowe 1993 [1], Anstee, et al 1994a [2]). The antigens of 18 blood group systems are defined by the sequence of proteins which are intrinsic to the red cell. The primary sequence of proteins responsible for the antigens of 15 of these systems is known from sequencing cDNA (reviewed in Anstee 1994 [3]). Partial sequence information is available for the JK (urea transporter) protein [4]. The proteins giving rise to SC and DO antigens have been identified but no sequence information is yet available [5, 6].

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Authors
  1. D. J. Anstee
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  2. P. A. Judson
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Leiden, The Netherlands

    E. Briët

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© 1995 Springer Science+Business Media Dordrecht

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Anstee, D.J., Judson, P.A. (1995). The Molecular Biology of Blood Groups: Relevance to the Study of Erythroid Maturation and the Clinical Management of Haemolytic Disease of the Newborn. In: Sibinga, C.T.S., Das, P.C., Briët, E. (eds) Hereditary Diseases and Blood Transfusion. Developments in Hematology and Immunology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2017-7_8

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  • DOI: https://doi.org/10.1007/978-1-4615-2017-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5834-3

  • Online ISBN: 978-1-4615-2017-7

  • eBook Packages: Springer Book Archive

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