Abstract
The identification and cloning of the factor VIII (FVIII) and factor IX (FIX) genes in the 1980’s opened up the possibility of not only detailed studies of the molecular basis of the haemophilias, but also practical techniques for accurate carrier detection and prenatal diagnosis. The cloning of the genes has also led to the production of recombinant FVIII and FIX, the former now licensed for use in several countries, and to the exciting possibility of gene therapy.
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Peake, I.R. (1995). The Molecular Biology of Haemophilia. In: Sibinga, C.T.S., Das, P.C., Briët, E. (eds) Hereditary Diseases and Blood Transfusion. Developments in Hematology and Immunology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2017-7_1
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DOI: https://doi.org/10.1007/978-1-4615-2017-7_1
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