Abstract
Excessive release or administration of beta-mimetic catecholamines may induce cardiomegaly, necrotic lesions and accumu-lation of connective tissue in the heart of adult homoiotherms. It was examined here whether similar changes can also be observed at different stages of evolution of the cardiovascular system, i.e. in poikilotherms and in homoiotherms during embryonic life.
Sensitivity of the poikilothermic hearts (carp, frog, turtle) to isoproterenol (IPRO) was significantly lower than in the homoiotherms. Necrotic lesions, if present, were localized in the inner spongious musculature which has no vascular supply but which exhibits higher activities of enzymes connected with aerobic oxidation. Moreover, the IPRO-induced decrease of the phospholipid content was also significantly more expressed in the spongious layer. IPRO treatment did not influence the total weight of the fish heart but the proportion of the outer compact layer was significantly higher. These changes were accompanied by an increase of collagen, higher water content and an increase of isomyosin with a lower ATPase activity. The response of the poikilothermic heart to IPRO-induced overload thus differs significantly from that in the homoiotherms.
The administration of IPRO during embryonic life of homoiotherms (chick) induces serious cardiovascular disturbances, including cardiomegaly and cellular oedema. Necroses of myofibrils, characteristic of IPRO-induced lesions of adults, were, however, rather exceptional. IPRO did not elevate the concentration of 85Sr (as a calcium homologue) in the immature myocardium; it seems, therefore, that IPRO-induced changes of the embryonic heart are not necessarily due to an intracellular calcium overload.
It may be concluded that the character of catecholamine-induced cardiomyopathy is not uniform and depends strictly on the stage of cardiac development. (Mol Cell Biochem 147: 83–88, 1995)
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References
Rona G: Catecholamine cardiotoxicity. J Mol Cell Cardiol 17: 291–306, 1985
Dhalla NS, Yates JC, Naimark B, Dhalla KS, Beamish RE, Okádal B: Cardiotoxicity of catecholamines and related agents. In: D. Acosta (ed). Cardiovascular Toxicology. New York, Raven Press, 1992, pp 239–283
Rona G, Chappel CI, Balasz T, Gaudry R: An infarct-like myocardial lesions and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 67: 443–455, 1959a
Rona G, Zsoter T, Chappel C, Gaudry R: Myocardial lesions, circulatory and electrographic changes produced by isoproterenol in the dog. Rev Can Biol 18: 83–94, 1959b
Handforth CP: Myocardial infarction and necrotizing arteritis in ham-sters, produced by isoproterenol (Isuprel). Med Sery J Can 18: 506–512, 1962
Amelin AZ, Anshelevich JV, Malzobar MJ: Eksperimentalnyje izmenenija miokarda pri vozdëjstvii izadrinom (isopropylnoradrenalinom). Arkh Pathol 25: 25–30, 1963
Rosenblum I, Wohl A, Stein AA: Studies in cardiac necrosis. I Production of cardiac lesion with symphathomimetic amines. Toxicol Appl Pharmacol 7: 1–8, 1965
Maruffo CA: Fine structural study of myocardial changes induced by isoproterenol in Rhesus monkeys (Macaca mulatta). Am J Pathol 50: 27–37,1967
Zbinden G, Moe RA: Pharmacologial studies on heart muscle lesions induced by isoproterenol. Ann NY Acad Sci 156: 294–308, 1969
Otiádal B, Rychterová V: Effect of necrogenic doses of isoproterenol on the tench (Tinca tinca — Osteoichthyes), the frog (Rana temporaria —Anura) and the pigeon (Columbia livia—Aves). Physiol Bohemoslov 20: 541–547, 1971
Benninghoff A Herz: In: L. Bolk, E. Göppert, E. Killius, W. Lubosch (eds). Handbuch vergleich. Mat Wirbeltiere, VI Band. Wien, Berlin, 1933
Poupa O, Otiádal B: Experimental cardiomegalies and `cardiome — galies’ in free living animals. Ann NY Acad Sci 156: 445–468, 1969
O§iádal B, Rychter Z, Poupa O: Comparative aspects of the development of the terminal vascular bed in the myocardium. Physiol Bohemoslov 19: 1–7, 1970
Bass A, Otiádal B, Pelouch V, Vitek V: Differences in weight parameters, myosin-ATPase activity and the enzyme pattern of energy supplying metabolism between the compact and spongious cardiac musculature of carp (Cyprinus carpio) and turtle (Testudo Horsfieldi). Pflügers Arch 343: 65–77, 1973
Dmková J, Nováková O, Pelouch V, Ottádal B, Kubiáta V: Phospholipid content in the compact and spongious musculature of the carp heart (Cyprinus carpio). Physiol Bohemoslov 34: 381–384, 1985
Maresca B, Modigh M, Servillo L, Tota B: Different temperature dependences of oxidative phosporylation in the inner and outer layers of tuna heart ventricle. J Comp Physiol 105: 167–172, 1976
Greco G, Martino G, Tota B: Further characterization of two mitochondrial populations in tuna heart ventricle. Comp Biochem Physiol 71B: 71–75, 1982
Oktádal B, Rychterová V, Poupa O: Isoproterenol-induced acute experimental cardiac necrosis in the turtle (Testudo Horsfieldi). Am Heart J 76: 645–649, 1968
Gemelli L, Martino G, Tota B: Oxidation of lactate in the compact and spongy myocardium of tuna fish (Thunnus thynnus thynnus L.). Comp Biochem Physiol 65B: 231–236, 1980
Karlsten A, Akholm LE, Poupa O: Ultrastructural and functional aspects of frog heart lesions after isoproterenol. Acta Path Microbiol Scand 85: 251–267, 1977
Pelouch V, Okiádal B, Zerveny M, Procházka J: Isoprenaline-induced cardiac enlargement in fish. J Mol Cell Cardiol 15: 221, 1983
Drnková J, Nováková O, Pelouch V, OS1ádal B, Kubi§ta V: The effect of isoprenaline on the phospholipid content of the compact and spongious musculature of the carp ventricular myocardium. Comp Biochem Physiol 90C: 257–261, 1988
Rakulan K, Tietzová H, Turek Z, Poupa O: Cardiomegaly after repeated application of isoprenaline in the rat. Physiol Bohemoslov 14: 456–459, 1965
Stanton HC, Brenner G, Mayfield ED: Studies on isoproterenol-induced cardiomegaly in rats. Am Heart J 77: 72–80, 1969
Cihák R, Koláf F, Pelouch V, Procházka J, O§iádal B, Widimsky J: Functional changes in the right and left ventricle during the development of cardiac hypertrophy and after its regression. Cardiovasc Res 26: 845–850, 1992
Oçce dal B, Schiebler TH: Uber die terminale Strombahn in Fischherzen. Z Anat Entwickl-Gesch 133: 288–304, 1971
Vorbeck ML, Malewski FF, Erhart LS, Martin AP: Membrane phospholipid metabolism in the isoproterenol-induced cardiomyopathy in the rat. In: A. Fleckenstein, G. Rona (eds). Recent Advances in the Study of Cardiac Structure and Metabolism. University Press, Baltimore, 1975, pp 175–181
Dhalla NS, D§urba A, Pierce GN, Tregaskis MG, Panagia V, Beamish RE: Membrane changes in myocardium during catecholamine-induced pathological hypertrophy. In: N.R. Alpert (ed). Perspectives in Cardiovascular Research. Raven Press, New York, 1983, pp 527–534
Dhalla NS, Ganguly PK, Panagia V, Beamish RE: Catecholamineinduced cardiomyopathy: alterations in Ca transport systems. In: C. Kawai, W.H. Abelman (eds). Pathogenesis of Myocarditis and Cardiomyopathy. University of Tokyo Press, Tokyo, 1987, pp 135–147
Okumura K, Ogawa K, Satake T: Pretreatment with chlorpromazine prevents phospholipid degradation and creatine kinase depletion in isoproterenol-induced myocardial damage in rats.’ J Cardiovasc Pharmac 5: 983–988, 1983
Brown JH, Buxton IL, Bruton LL: Alfal-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes. Circ Res 57: 532–537, 1985
Kiss Z, Farkas T: The effect of isoproterenol on the metabolism of phosphatidylinositol by rat heart in vitro. Biochem Pharmac 24: 999–1002, 1975
Nuwayhid B, Rajabi M: Beta-sympathomimetic agents: Use in perinatal obstetrics. Clin Perinatol 14: 757–782, 1987
Driscoll DJ: Use of inotropic and chronotropic agents in neonates. Clin Perinatol 14: 931–948, 1987
Papp J Gy: Autonomic responses and neurohumoral control in the early antenatal heart. Basic Res Cardiol 83: 2–9, 1988
Oçoe dal B, Beamish RE, Barwinsky J, Dhalla NS: Ontogenic development of cardiac sensitivity to catecholamines. J Appl Cardiol 4: 467–486, 1989
Oçce dal B, Rychter Z, Owe dalová I: Ontogenic development of cardiotoxicity for catecholamines. In: M. Nagano, T. Takeda, N.S. Dhalla (eds). The Cardiomyopathic Heart. Raven Press, New York,1994, pp 395–400
Oçoe dal B, Rychter Z, Rychterová V: The action of isoproterenol on the chick embryo heart. J Mol Cell Cardiol 8: 533–544, 1976
Rychter Z, Oçce dal B: The relationship between the dose of beta mimetic catecholamines and type of induced cardiovascular anomalies in early chick embryo. Verh Anat Ges 80: 275 27, 1986
Caritis SN, Shei Lin L, Toig G, Wonk LK: Pharmacodynamics of ritodrine in pregnant women during pre-term labor. Am J Obstet Gynecol 147: 752–759, 1983
Oçce dal B: Phylogenetic and ontogenetic development of the terminal vascular bed in the heart muscle and its effect on the development of experimental cardiac necrosis. In: Proceedings of the Second Annual Meeting of the Inter Study Gr for Res in Cardiac Metabolism, Instituto Lombardo, Milano. Fond Baselli, 1970, pp 111–132
Fleckenstein A: Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions. In: P. Harris, L.H. Opie (eds). Calcium and the Heart. Academic Press, London, 1971, pp 135–188
Mr z M, Faltov E, ediv y J, Protivov J, Piln J: Quantitative evaluation of the development of isoprenaline-induced heart lesions. Physiol Bohemoslov 29: 323–331, 1980
Hodach RJ, Hodach AE, Fallon JD, Bruyere HJ, Gilbert EF: The role of beta adrenergic activity in the production of cardiac aortic arch anomalies in chick embryos. Teratology 12: 33–46, 1975
Oçoe dal B, Janatová T, Krause EG, Pelouch V, Dusek J: Different effect of propranolol and verapamil on isoprenaline-induced changes in the chick embryonic heart. Physiol Bohemoslov 36: 301–311, 1987
Oçce dalová I, Oçce dal B: Effect of isoprenaline on “Sr accumulation in the myocardium of the adult rat. Physiol Bohemoslov 37: 351–353, 1988
Oçce dalová I, Oçoedal B: “Sr uptake by the chick embryonic heart: effect of high doses of isoproterenol. Can J Physiol Pharmacol 70: 959–962, 1992
Oçce dalová I, Oçce dal B: Ontogenic differences in isoproterenol-induced “Sr uptake in the myocardium. In: M. Nagano, N. Takeda, N.S. Dhalla (eds). The Cardiomyopathic Heart. Raven Press, New York, 1993, pp 395–400
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Ošťádal, B., Pelouch, V., Ošťádalová, I., Nováková, O. (1995). Structural and biochemical remodelling in catecholamine-induced cardiomyopathy: comparative and ontogenetic aspects. In: Slezák, J., Ziegelhöffer, A. (eds) Cellular Interactions in Cardiac Pathophysiology. Developments in Molecular and Cellular Biochemistry, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2005-4_11
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DOI: https://doi.org/10.1007/978-1-4615-2005-4_11
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