Abstract
The importance to breathing of neurons in the ventrolateral medulla (VLM) was first shown by studies that manipulated the environment of the surface of the VLM. For example, cooling probes applied to a specific area on the surface of the VLM can profoundly depress ventilatory output and CO2 sensitivity in anesthetized (4, 9, 10, 24) and conscious animals (7). The investigators named this surface site the intermediate area because it lay between two adjacent surface areas associated with central chemosensitivity. They proposed it to be integrative in function (4, 9, 10, 24).
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Nattie, E.E., Li, A. (1995). Retrotrapezoid Nucleus (RTN) Metabotropic Glutamate Receptors and Long-Term Stimulation of Ventilatory Output. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_8
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