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Clinical Considerations in Vaccine Trials with Special Reference to Candidate HIV Vaccines

  • Chapter
Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

Clinical research on HIV-1 vaccine candidates, which began less than a decade ago, illustrates many facets of vaccine trials in general. At each step, however, from gaining public acceptance for the trial and recruiting volunteers to evaluation of data, unique problems have arisen. In this chapter, we will discuss clinical evaluation of HIV-1 vaccines as both a paradigm and a special case of vaccine clinical trials. We will emphasize prophylactic use of vaccines.

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  1. Vaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Patricia E. Fast, Leigh A. Sawyer & Susan L. Wescott

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    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

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Fast, P.E., Sawyer, L.A., Wescott, S.L. (1995). Clinical Considerations in Vaccine Trials with Special Reference to Candidate HIV Vaccines. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_5

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