Abstract
Vaccination represents the most successful attempt yet to protect humans and domestic animals from infectious diseases. Most vaccines operate by limiting infections, not necessarily by preventing them; it is the host immune system that mediates control and ultimate clearance of the infectious agent. Many of the most widely used vaccines developed for use in humans are based on live replicating organisms that have been attenuated. Vaccination with these agents results in a limited infection, but measurable disease pathogenesis is usually avoided and recovery is complete. The resultant immune responses are protective against the fully virulent pathogens and long-term immunological memory is induced. Today, attenuated vaccines are still used and efforts to develop the next generation are active.
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Newman, M.J., Powell, M.F. (1995). Immunological and Formulation Design Considerations for Subunit Vaccines. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_1
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