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Genetic Mutants With Dysregulation of Corticotropin Pathways

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Transgenic Models in Endocrinology

Part of the book series: Endocrine Updates ((ENDO,volume 13))

Abstract

This review emphasizes emerging concepts in regulation of the hypothalamicpituitary-adrenal (HPA) axis. We first discuss relevant physiologic pathways and molecular mechanisms that control the HPA axis. Imbalances at many levels can disrupt HPA axis homeostasis leading to conditions such as Cushing’s syndrome, pituitary hyperplasia, and anxiety disorders. We then describe recently developed animal models with specific alterations in corticotropin pathways. The primary elements of these pathways have been engineered for upregulation, downregulation or deficiency and thus provide a powerful collection of models for studying HPA axis regulation. These models provide new views into features critical for maintaining control of the HPA axis. They have expanded our understanding of the degree of plasticity and compensation that exists within this system. In addition, they reveal novel mechanisms whereby inappropriate or absent regulatory components lead to abnormal endocrine manifestations and behavioral states.

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Authors and Affiliations

  1. Oregon Health Sciences University, Portland, OR

    Susan E. Murray, Sarah C. Coste, Iris Lindberg & Mary P. Stenzel-Poore

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  1. Susan E. Murray
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  2. Sarah C. Coste
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  3. Iris Lindberg
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  4. Mary P. Stenzel-Poore
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Editors and Affiliations

  1. The University of Manchester, UK

    Maria G. Castro Ph.D.

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© 2001 Springer Science+Business Media New York

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Murray, S.E., Coste, S.C., Lindberg, I., Stenzel-Poore, M.P. (2001). Genetic Mutants With Dysregulation of Corticotropin Pathways. In: Castro, M.G. (eds) Transgenic Models in Endocrinology. Endocrine Updates, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1633-0_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1633-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5651-6

  • Online ISBN: 978-1-4615-1633-0

  • eBook Packages: Springer Book Archive

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