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Soy and Risk of Hormone-Related and Other Cancers

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Nutrition and Cancer Prevention

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 492))

Abstract

For the last presentation in this session on soy and cancer, I will cover the epidemiologic evidence on soy and several hormone-related and other cancers. My comments will focus on breast, endometrium and prostate cancers, three hormone-related cancer sites. The role of soy has been also investigated in several non-hormone related cancers including colorectal, stomach and lung cancer. As Dr. Maurice Bennink has just given an excellent presentation on colorectal cancer, my remarks will be limited to stomach and lung cancers.

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References

  1. Adlercreutz, H. Western diet and western disease: some hormonal and biochemical mechanisms and associations. Scand. J. Clin. Lab Invest. Suppl. 1990; 50:3–23.

    Article  Google Scholar 

  2. Barnes, S. Phytoestrogens and breast cancer. Bailliere’s Clinical Endo. Metab. 1998; 12: 559–79.

    Article  CAS  Google Scholar 

  3. Chen, Z., Zheng, W., Custer, L.J., Dai, Q., Shu, X.O., Jin, F., Franke, A.A. Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutr. Cancer 1999; 33: 82–7.

    Article  PubMed  CAS  Google Scholar 

  4. Coward, L., Barnes, N.C., Setchell, K.D.R., Barnes, S. Genistein, daidzein, and their b-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets. J. Agric. Food Chem. 1993; 4: 1961–7.

    Article  Google Scholar 

  5. Goodman, M.T., Wilkens, L.R Hankin, J.R., Lyu, L.C., Wu, A.H., Kolonel, L.N. Association of soy and fiber consumption with the risk of endometrial cancer. Am. J. Epidemiol. 1997; 146: 294–306.

    Article  PubMed  CAS  Google Scholar 

  6. Greenwald, P. Role of dietary fat in the causation of breast cancer: Point. Cancer Epidemiology, Biomarkers and Prey 1999 ; 8: 3–7.

    CAS  Google Scholar 

  7. Horn-Ross, P.L., Barnes, S., Lee, M., Coward, L., Mandel, E., Koo, J John, E.M., Smith, M. Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States). Cancer Causes and Control 2000; 11: 289–298.

    Article  PubMed  CAS  Google Scholar 

  8. Hirayama, T. Life-style and mortality. A large-scale census-based cohort study in Japan. In: Contributions to Epidemiology and Biostatistics. Vol 6. Wahrendorf, J . (eds). Karger, Basel. 1990.

    Google Scholar 

  9. Hirose, K., Tajimak, K., Hamajimak, N., Inouek, M., Takezaki, T., Kuroishi, T., Yoshida, M., Tokudome, S. A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status. Jpn. J. Cancer Res. 1995; 86: 146–154.

    Article  PubMed  CAS  Google Scholar 

  10. Hu, J., Johnson, K.C., Mao, Y., Xu, T., Lin, Q., Wang, C., Zhao, F., Wnag, G., Chen, Y., Yang, Y. A case-control study of diet and lung cancer in Northeast China. Int. J. Cancer 1997; 71: 924–31.

    Article  PubMed  CAS  Google Scholar 

  11. Hunter, D.J. Role of dietary fat in the causation of breast cancer: Counterpoint. Cancer Epidemiology , Biomarkers and Prey 1999; 8: 9–14.

    CAS  Google Scholar 

  12. Ingram, D., Sanders, K Kolybaba, M. Case-control study of phyto-estrogens and breast cancer. Lancet 1997; 350: 990–4, 1997.

    Google Scholar 

  13. Jacobsen, B.K., Knutsen, S.F., Fraser, G.E. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes and Control 1998; 9: 553–557.

    Article  PubMed  CAS  Google Scholar 

  14. Key, T.J., Sharp, G.B., Appleby, P.N., Beral, V., Goodman, M.T., Soda, M., Mabuchi, K. Soya foods and breast cancer risk: A prospective study in Hiroshima and Nagasaki, Japan. Br. J. Cancer 1999; 81: 1248–1256.

    Article  PubMed  CAS  Google Scholar 

  15. Kirk, P., Patterson, R.E., Lampe, L. Development of a soy food frequency questionnaire to estimate isoflavone consumption in US adults. J. Am Diet Assoc. 1999; 99: 558–563.

    Article  PubMed  CAS  Google Scholar 

  16. Kolonel, L.N., Hankin, J.H., Whittemoore, A.S., Wu, A.H., Gallagher, R.P., Wilkens, L.R., John, E.M., Howe, G.R., Dreon, D.M., West, D.W., Paffenbarger, R.S., Jr. Vegetables, fruits, legumes and prostate cancer: A multiethnic case-control study. Cancer Epidemiol. , Biomarkers and Prey 2000; 9:795–804.

    CAS  Google Scholar 

  17. Koo, L.C. Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. Nutr. Cancer 1988; 11: 155–72.

    Article  PubMed  CAS  Google Scholar 

  18. Lampe, J.W., Gustafson, D.R., Hutchins, A.M., Martini, M.C., Li, S., Wahala, K., Grandits, G.A., Potter, D.J., Slavin, J.L. Urinary isoflavonoid and lignan excretion on a Western diet: relation to soy, vegetable and fruit intake. Cancer Epidemiol, Biomarkers and Prey 1999; 8:699–707.

    CAS  Google Scholar 

  19. Lee, H.P., Gourley, L., Duffy, S.W., Esteve, J., Lee, J., Day, N.E. Dietary effects on breast-cancer risk in Singapore. Lancet 1991;331:1197–200.

    Article  Google Scholar 

  20. Lee, M.M., Wang, R.T., Hsing, A.W., et al. Case-control study of diet and prostate cancer in China. Cancer Causes and Control 1998; 9: 545–552.

    Article  PubMed  CAS  Google Scholar 

  21. Murphy, P.A., Song, T.T., Buseman, G., Barua, K., Beecher, G.R., Trainer D, Holden J. Isoflavones in retail and institutional soy foods. J. Agric. Food Chem. 1999; 47:2697–2704.

    Article  PubMed  CAS  Google Scholar 

  22. Nagata, C., Takatsuka, N., Inaba, S., Norito, K. and Shimizu, H. Effect of soymilk consumption on serum estrogen concentrations in premenopausal Japanese women. J. Natl. Cancer Inst. 1998; 90:1980–1985.

    Article  Google Scholar 

  23. Nomura, A. “Stomach Cancer.” In Cancer Epidemiology and Prevention, D.Schottenfeld, J.F. Fraumeni, Jr, eds. New York, Oxford Press, 1996.

    Google Scholar 

  24. Oishi, K., Okada, K., Yoshida, O., Tamaba, H., Ohno, Y., Hayes, R.B., Schroeder, F.H. A case-control study of prostatic cancer with reference to dietary habits. The Prostate 1988; 12: 179–190.

    Article  PubMed  CAS  Google Scholar 

  25. Severson, R.K., Nomura, A.M.Y., Grove, J.S., Stemmermann, G.N. A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res. 1989; 49: 1857–1860.

    PubMed  CAS  Google Scholar 

  26. Shu, X.O., Zheng, W., Potischman, N., Brinton, LA., Hatch, M.C., Gao, Y.T., Fraumeni, J.F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People’s Republic of China. Am. J. Epidemiol. 1993; 137: 155–165.

    PubMed  CAS  Google Scholar 

  27. Strom, S.S., Yamamura, Y., Duphorne, C.M., Spitz, M.R., Babaian, R.J., Pillow, P.J., Hursting, S.D. Phytoestrogen intake and prostate cancer: A case-control study using a new database. Nutr. Cancer 1999; 33: 20–5.

    Article  PubMed  CAS  Google Scholar 

  28. Swanson, C.A., Mao, B.L., Li, J.Y., Lubin, J.H., Yao, S.X., Wang, J.Z., Cai, S.K., Hou, Y., Luo, Q.S., Blot, W.J. Dietary determinants of lung cancer risk: Results from a case-control study in Yunnan Province, China. Int. J. Cancer 1992; 50: 87680.

    Google Scholar 

  29. Wakai K., Egami, I., Kato, K., Kawamura, T., Tamakoshi, A., Lin, Y., Nakayama, T., Wada, M. and Ohno, Y. Dietary intake and sources of isoflavones among Japanese. Nutr. Cancer 1999a; 33: 139–145.

    Article  CAS  Google Scholar 

  30. Wakai, K., Ohno, Y., Genka, K., Ohmine, K., Kawamura, T., Tamakoshi, A., Lin, Y., Nakayama, T., Aoki, K., Fukuma, S. Risk modifications in lung cancer by a dietary intake of preserved foods and soyfoods: findings from a case-controlled study in Okinawa, Japan. Lung Cancer 1999b; 25:147–159.

    Article  CAS  Google Scholar 

  31. Wang, H.J. and Murphy, P.A. Isoflavone content in commercial soybean foods. J. Agric. Food Chem. 1994; 42: 1666–1673.

    Article  CAS  Google Scholar 

  32. Witte, J.S., Ursin, G., Siemiatycki, J., Thompson, W.D., Paganini-Hill, A., Haile, R.W. Diet and premenopausal bilateral breast cancer: a case-control study. Breast Cancer Res. Treat. 1997; 42: 243–551.

    Article  PubMed  CAS  Google Scholar 

  33. Wu, A.H., Ziegler, R.C., Horn-Ross, P.L., Nomura, A.M.Y., Weot, D.W., Kolonel, L.N., Rosenthal, J.F., Hoover, R.N., Pike, M.C. Tofu and risk of breast cancer in Asian-Americans. Pike Cancer Epidemiol. Biomarkers Prey. 1996; 5: 901–6.

    CAS  Google Scholar 

  34. Wu, A.H., Yang, D., Pike, M.C. A meta-analysis of soy foods and risk of stomach cancer: The problem of potential confounders. Cancer Epidemiol., Biomarkers and Prey 2000; 9: 1051–1058.

    CAS  Google Scholar 

  35. Wu-Williams, A.H., Dai, X.D., Blot, W., Xu, Z.Y., Sun, X.W., Xiao, H.P., Stone, B.J., Yu, S.F., Feng, Y.P., Ershow, A.G., Sun, J., Fraumeni, J.R., Jr., Henderson, B.E. Lung cancer among women in north-east China. Br. J. Cancer 1990; 62: 982–7.

    Article  PubMed  CAS  Google Scholar 

  36. Yuan, J.M., Wang, Q.S., Ross, R.K., Henderson, B.E., Yu, M.C. Diet and breast cancer in Shanghai and Tianjin, China. Br. J. Cancer 1995; 71: 1353–8.

    Article  PubMed  CAS  Google Scholar 

  37. Zheng, W., Dai, Q., Custer, L.J., Shu, X.O., Wen, W.Q., Jin, F., Franke, A.A. Urinary excretion of isoflavonoids and the risk of breast cancer. Cancer Epidemiol. Biomark Prey. 1999; 8: 35–40.

    CAS  Google Scholar 

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  1. University of Southern California, Department of Preventive Medicine, 1441 Eastlake Avenue, MS#44, Los Angeles, CA, 90089

    Anna H. Wu Ph.D.

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  1. Anna H. Wu Ph.D.
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    © 2001 Springer Science+Business Media New York

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    Wu, A.H. (2001). Soy and Risk of Hormone-Related and Other Cancers. In: Nutrition and Cancer Prevention. Advances in Experimental Medicine and Biology, vol 492. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1283-7_3

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    • DOI: https://doi.org/10.1007/978-1-4615-1283-7_3

    • Publisher Name: Springer, Boston, MA

    • Print ISBN: 978-1-4613-5477-2

    • Online ISBN: 978-1-4615-1283-7

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