Abstract
Understanding the effect of neuromodulators requires modeling the dynamics of second messenger pathways and their effects on channel properties. Chemesis is software for modeling enzyme reactions, stoichiometric reactions, diffusion, and ligand gating of channels and is used in conjunction with GENESIS, the software program for neuronal modeling. This chapter explains the differential equations and corresponding Chemesis objects that implement these reactions. Glutamate stimulated IP3 production and calcium waves are examples of the second messenger pathways that can be implemented in Chemesis.
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Blackwell, K.T., Kotaleski, J.H. (2003). Modeling The Dynamics of Second Messenger Pathways. In: Kötter, R. (eds) Neuroscience Databases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1079-6_5
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DOI: https://doi.org/10.1007/978-1-4615-1079-6_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5384-3
Online ISBN: 978-1-4615-1079-6
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