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Novel Therapies for Renal Cell Carcinoma

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Kidney Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 116))

Abstract

The treatment of advanced renal cell carcinoma presents a daunting challenge to medical, surgical and radiation oncologists. Although patients with localized renal cell carcinoma can be effectively treated by surgery with a 5 year survival of up to 88%, the treatment options are limited for patients with advanced disease with the 5 year survival rate under 10%.1’2Furthermore, systemic chemotherapeutic agents have had little impact on the natural history of this disease. A comprehensive review by Yagodaet at 3encompassed 4542 patients enrolled in 83 clinical trials published from 1983 through 1993. Among the 4093 evaluable patients, a 6% overall response rate was determined which was comprised of 53 (1.3%) complete responses and 192 (4.7%) partial responses. This dismal level of antitumor activity is comparable to the reported rate of spontaneous objective responses observed for placebo treated patients entered in a randomized study.4

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Authors and Affiliations

  1. Division of Medical Oncology, University of Texas Health Science Center at San Antonio, Texas, USA

    Samira Syed M.D.

  2. Associate Director Clinical Research, Institute for Drug Development, Cancer Therapy and Research Center and Associate Clinical Professor of Medicine, University of Texas Health Science Center at San Antonio, USA

    Anthony W. Tolcher M.D., FRCP(C)

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  1. Samira Syed M.D.
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  2. Anthony W. Tolcher M.D., FRCP(C)
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  1. University of California, Los Angeles, CA, USA

    Robert A. Figlin

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Syed, S., Tolcher, A.W. (2003). Novel Therapies for Renal Cell Carcinoma. In: Figlin, R.A. (eds) Kidney Cancer. Cancer Treatment and Research, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0451-1_14

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  • DOI: https://doi.org/10.1007/978-1-4615-0451-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5083-5

  • Online ISBN: 978-1-4615-0451-1

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