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Function of PACAP in the Adrenal Cortex

  • Chapter
Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

Compelling evidence indicates that PACAP plays a potentially important role in the regulation of adrenal-cortex secretion and growth, mainly acting indirectly on its parenchymal cells. PACAP enhances ACTH secretion from pituitary corticotropes (Malagon et al, 2002), and ACTH activates aldosterone and glucocorticoid production from adrenal zona glomerulosa (ZG) and zonae fasciculata-reticularis (ZF/R), respectively, as well as stimulates adrenal growth (hypertrophy and hyperplasia) (Nussdorfer, 1986; Vinson et al, 1992). Moreover, PACAP enhances catecholamine release from medullary chromaffin cells (Hamelink et al, 2002b), and catecholamines acting in a paracrine manner are able to raise steroid-hormone secretion through the activation of P-adrenoceptors located on adrenocortical cells (Nussdorfer, 1996).

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Reference

  • Alexander LD, Sander LD. Vasoactive intestinal peptide stimulates ACTH and corticosterone release after injection into the PVN. Regul Pept 1994;51:221–227.

    Article  PubMed  CAS  Google Scholar 

  • Alexander LD, Sander LD. Involvement of vasopressin and corticotropin-releasing hormone in VIP- and PHI-induced secretion of ACTH and corticosterone. Neuropeptides 1995;28:167–173.

    Article  PubMed  CAS  Google Scholar 

  • Ambrosi B, Bochicchio D, Sartorio A, Morabito F, Faglia G. Vasoactive intestinal polypeptide enhances ACTH levels in some patients with adrenocorticotropin-secreting pituitary adenoma. Acta Endocrinol (Copenh) 1987;116:216–220.

    CAS  Google Scholar 

  • Anderova M, Duchene AD, Barbara JG, Takeda K. Vasoactive intestinal peptide potentiates and directly stimulates catecholamine secretion from rat adrenal chromaffin cells. Brain Res 1998;809:97–106.

    Article  PubMed  CAS  Google Scholar 

  • Andreis PG, Malendowicz LK, Belloni AS, Nussdorfer GG. Effects of pituitary adenylate cyclase-activating peptide (PACAP) on the rat adrenal secretory activity: preliminary in vitro studies. Life Sci 1995;56:135–142.

    Article  PubMed  CAS  Google Scholar 

  • Arimura A, Somogyvari-Vigh A, Miyata A, Mizuno K, Coy DH, Kitada C. Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology 1991;129:2787–2789.

    Article  PubMed  CAS  Google Scholar 

  • Arimura A, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interactions. Front Neuroendocrinol 1995;16:53–58.

    Article  PubMed  CAS  Google Scholar 

  • Arimura A. Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn J Physiol 1998;48:301–331.

    Article  PubMed  CAS  Google Scholar 

  • Barbara JG, Takeda K. Voltage-dependent currents and modulation of calcium channel expression in zona fasciculata cells from rat adrenal gland. J Physiol (Lond) 1995;488:609–622.

    CAS  Google Scholar 

  • Barrie AP, Clohessy AM, Buensuceso CS, Rogers MV, Allen JM. Pituitary adenylyl cyclaseactivating peptide stimulates extracellular signal-regulated kinase 1 or 2 (ERK1/2) activity in a Ras-independent, mitogen-activated protein kinase/ERK kinase 1 or 2-dependent manner in PC12 cells. J Biol Chem 1997;272:19666–19671.

    Article  PubMed  CAS  Google Scholar 

  • Bernet F, Bernard J, Laborie C, Montei V, Maubert E, Dupouy JP. Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerulosa zone could be mediated by catecholamines via 131 adrenergic receptors. Neurosci Lett 1994;166:109–112.

    Article  PubMed  CAS  Google Scholar 

  • Bloom SR, Edwards AV, Jones CT. Adrenal cortical responses to vasoactive intestinal peptide in conscious hypophysectomized calves. J Physiol (Lond) 1987;391:441–450.

    CAS  Google Scholar 

  • Bodart V, Babinski K, Ong H, De Lean A. Comparative effect of pituitary adenylate cyclaseactivating polypeptide on aldosterone secretion in normal bovine and human tumorous adrenal cells. Endocrinology 1997;138:566–573.

    Article  PubMed  CAS  Google Scholar 

  • Bodnar M, Sarrieau A, Deschepper CF, Walker CD. Adrenal vasoactive intestinal peptide participates in neonatal corticosteroid production in the rat. Am J Physiol 1997;273:R1163–R1172.

    PubMed  CAS  Google Scholar 

  • Bornstein SR, Ehrhart-Bornstein M, Stromeyer HG, Adler G, Scherbaum WA, Hoist JJ. Vasoactive intestinal peptide (VIP) stimulates androstenedione release in isolated perfused pig adrenals. Life Sci 1992;52:135–140.

    Article  Google Scholar 

  • Bornstein SR, Haidan A, Ehrhart-Bornstein M. Cellular communication in the neuroadrenocortical axis: role of vasoactive intestinal polypeptide (VIP). Endocr Res 1996;22:819–829.

    PubMed  CAS  Google Scholar 

  • Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA. Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland. Microsc Res Tech 1997;36:520–533.

    Article  PubMed  CAS  Google Scholar 

  • Breault L, Yon L, Montero M, Chouinard L, Contesse V, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N. Occurrence and effect of PACAP in the human fetal adrenal gland. Ann NY Acad Sci 2000;921:429–433.

    Article  PubMed  CAS  Google Scholar 

  • Choi HJ, Park SY, Hwang 0. Differential involvement of PKA and PKC in regulation of catecholamine enzyme gene by PACAP. Peptides 1999;20:817–822.

    Article  PubMed  CAS  Google Scholar 

  • Cobb VJ, Williams BC, Mason JI, Walker SW. Direct stimulation of cortisol secretion from the human NCI-H295 adrenocortical cell line by vasoactive intestinal polypeptide. J Hypertens 1997;15:1735–1738.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham LA, Holzwarth MA. Autoradiographic distribution of 125I-VIP binding in the rat adrenal cortex. Peptides 1989;10:1105–1108.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham LA, Holzwarth MA. Vasoactive intestinal peptide stimulates adrenal aldosterone and corticosterone secretion. Endocrinology 1988;122:2090–2097.

    Article  PubMed  CAS  Google Scholar 

  • Dun NJ, Tang H, Dun SL, Huang R, Dun EC, Wakade AR. Pituitary adenylate cyclaseactivating polypeptide-immunoreactive sensory neurons innervate rat adrenal medulla. Brain Res 1996;716:11–21.

    Article  PubMed  CAS  Google Scholar 

  • Ehrhart-Bornstein M, Bornstein SR, Scherbaum WA, Pfeiffer EF, Hoist JJ. Role of vasoactive intestinal peptide in a neuroendocrine regulation of the adrenal cortex. Neuroendocrinology 1991;54:623–628.

    Article  PubMed  CAS  Google Scholar 

  • Frodin M, Hannibal J, Wulff BS, Gammeltoft S, Fahrenkrug J. Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitor effect on chromaffin cells. Neuroscience 1995;65:599–608.

    Article  PubMed  CAS  Google Scholar 

  • Geng G, Gaspo R, Trabelsi F, Yamaguchi N. Role of L-type Ca2+ channel in PACAP-induced adrenal catecholamine release in vivo. Am J Physiol 1997;273:R1339–1345.

    PubMed  CAS  Google Scholar 

  • Ghatei MA, Takahashi K, Suzuki Y, Gardiner J, Jones PM, Bloom SR. Distribution and molecular characterization of pituitary adenylate cyclase-activating polypeptide and its precursor encoding messenger RNA in human and rat tissues. J Endocrinol 1993;136:159166.

    Article  Google Scholar 

  • Ginda WJ, Nussdorfer GG, Malendowicz LK. Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals. Horm Metab Res 1999;31:367–369.

    Article  PubMed  CAS  Google Scholar 

  • Gray SL, Cummings KJ, Jirik FR, Sherwood NM. Targeted disruption of the pituitary adenylate cyclase activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism. Mol Endocrinol 2001;15:1739–1747.

    Article  PubMed  CAS  Google Scholar 

  • Hahm SH, Hsu CM, Eiden LE. PACAP activates calcium influx-dependent and -independent pathways to couple met-enkephalin secretion and biosynthesis in chromaffin cells. J Mol Neurosci 1998;11:43–56.

    Article  PubMed  CAS  Google Scholar 

  • Haidan A, Hilbers U, Bornstein SR, Ehrhart-Bornstein M. Human adrenocortical NCI-H295 cells express VIP receptors. Steroidogenic effect of vasoactive intestinal peptide (VIP). Peptides 1998;19:1511–1517.

    Article  PubMed  CAS  Google Scholar 

  • Hamelink C, Tjurmina 0, Damadzic R, Young WS, Weihe E, Lee HW, Eiden LE. Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci USA 2002a;99:461–466.

    Article  CAS  Google Scholar 

  • Hamelink C, Weihe E and Eiden LE. PACAP: an emergency response co-transmitter in the adrenal medulla. In Pituitary Adenylate Cyclase-Activating Polypeptide, Vaudry H and Arimura A, eds. Boston: Kluwer Academic Publishers 2002b;pp227–249.

    Google Scholar 

  • Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberrecht P, Said SI, Sreedharan SP, Wank SA, Waschek JA. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev 1998;50:265–270.

    PubMed  CAS  Google Scholar 

  • Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 1993;11:333–342.

    Article  PubMed  CAS  Google Scholar 

  • Hinson JP, Kapas S, Orford CD, Vinson GP. Vasoactive intestinal peptide stimulation of aldosterone secretion by the adrenal cortex may be mediated by the local release of catecholamines. J Endocrinol 1992;133:253–258.

    Article  PubMed  CAS  Google Scholar 

  • Hinson JP, Cameron LA, Purbrick A, Kapas S. The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leu-enkephalin on perfusion medium flow rate in the intact perfused rat adrenal. Regul Pept 1994a;51:55–61.

    Article  CAS  Google Scholar 

  • Hinson JP, Purbrick A, Cameron LA, Kapas S. The role of neuropeptides in the regulation of adrenal zona fasciculata/reticularis function: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, Met-and Leu-enkephalin, and neurotensin on corticosterone secretion in the intact perfused rat adrenal gland in situ. Neuropeptides 1994b;26:391–397.

    Article  CAS  Google Scholar 

  • Hinson JP, Kapas S. Effects of sodium depletion on the response of rat adrenal zona glomerulosa cells to stimulation by neuropeptides: actions of vasoactive intestinal peptide, enkephalin, substance P, neuropeptide Y, and corticotropin-releasing hormone. J Endocrinol 1995;146:209–214.

    Article  PubMed  CAS  Google Scholar 

  • Hinson JP, Ho MM, Vinson GP, Kapas S. Vasoactive intestinal peptide is a local regulator of adrenocortical function. Endocr Res 1996;22:831–838.

    PubMed  CAS  Google Scholar 

  • Hinson JP, Puddeford JR, Kapas S. Actions of vasoactive intestinal peptide on the rat adrenal zona glomerulosa. J Endocrinol 1999;161:51–57.

    Article  PubMed  CAS  Google Scholar 

  • Holgert H, Holmberg K, Hannibal J, Fahrenkrug J, Brimijoin J, Hartman B, Hokfelt T. PACAP in the adrenal gland: relationship with choline acetyltransferase, enkephalin, and chromaffin cells and effects of immunologic sympathectomy. Neuroreport 1996;20:297–301

    Article  Google Scholar 

  • Inoue M, Fujishiro N, Ogawa K, Muroi M, Sakamoto Y, Imanaga I, Shioda S. Pituitary adenylate cyclase-activating polypeptide may function as a neuromodulator in guinea pig adrenal medulla. J Physiol (Lond) 2000;528:473–487.

    Article  CAS  Google Scholar 

  • Kowal J, Horst I, Pensky J, Alfonzo M. A comparison of the effects of ACTH, VIP, and cholera toxin on adrenal cAMP and steroid synthesis. Ann NY Acad Sci 1977;297:314–328.

    Article  PubMed  CAS  Google Scholar 

  • Laburthe M, Couvineau A and Nicole P. Molecular pharmacology and structure-function analysis of PACAP/VIP receptors. In Pituitary Adenylate Cyclase-Activating Polypeptide, Vaudry H and Arimura A, eds. Boston: Kluwer Academic Publishers 2002;pp69–93.

    Google Scholar 

  • Lamouche S, Yamaguchi N. Role of PAC1 receptor in adrenal catecholamine secretion induced by PACAP and VIP in vivo. Am J Physiol 2001;280:R510–R518.

    CAS  Google Scholar 

  • Larcher A, Delarue C, Idres S, Vaudry H. Interactions between vasotocin and other corticotropic factors on the frog adrenal gland. J Steroid Biochem Mol Biol 1992;41:795–798.

    Article  PubMed  CAS  Google Scholar 

  • Leboulenger F, Benyamina M, Delarue C, Netchitailo P, Saint-Pierre S, Vaudry H. Neuronal and paracrine regulation of adrenal steroidogenesis: interactions between acetylcholine, serotonin, and vasoactive intestinal peptide (VIP) on corticosteroid production by frog interrenal tissue. Brain Res 1988;453:103–109.

    Article  PubMed  CAS  Google Scholar 

  • Leboulenger F, Leroux P, Delarue C, Tonon MC, Charnay Y, Dubois PM, Coy HD, Vaudry H. Colocalization of vasoactive intestinal peptide (VIP) and enkephalin in chromaffin cells of the adrenal gland of amphibia. Stimulation of corticosteroid production by VIP. Life Sci 1983;32:375–383.

    Article  PubMed  CAS  Google Scholar 

  • Leboulenger F, Perroteau I, Netchitailo P, Lihrmann I, Leroux P, Delarue C, Coy DH, Vaudry H. Action of vasoactive intestinal peptide (VIP) on amphibian adrenocortical function in vitro. Peptides 1984;4:299–303.

    Article  Google Scholar 

  • Li ZG, Queen G, La Bella FS. Adrenocorticotropin, vasoactive intestinal polypeptide, growth hormone-releasing factor, and dynorphin compete for common receptors in brain and adrenal. Endocrinology 1990;126:1327–1333.

    Article  PubMed  CAS  Google Scholar 

  • Lightly ERT, Walker SW, Bird IM, Williams BC. Subclassification of 0-adrenoceptors responsible for steroidogenesis in primary cultures of bovine adrenocortical zona fasciculata/reticularis cells. Br J Pharmacol 1990;99:706–712.

    Article  Google Scholar 

  • Magistretti PJ, Hof PR, Martin JL, Died M, Palacios JM. High and low affinity binding sites for vasoactive intestinal peptide (VIP) in the rat kidney revealed by light microscopic autoradiography. Regul Pept 1988;23:145–152.

    Article  PubMed  CAS  Google Scholar 

  • Malagon MM, Castano JP, Garcia-Navarro S, Martinez-Fuentes AJ and Gracia-Navarro F. Function of PACAP in the hypothalamo-pituitary complex. In Pituitary Adenylate Cyclase-Activating Polypeptide, Vaudry H and Arimura A, eds. Boston: Kluwer Academic Publishers 2002;pp153–183.

    Google Scholar 

  • Malendowicz LK, Nussdorfer GG. Unusual effect of prolonged vasoactive intestinal peptide (VIP) administration on the adrenal growth and corticosterone secretion in the rat. Neuropeptides 1993;25:145–150.

    Article  PubMed  CAS  Google Scholar 

  • Mazzocchi G, Robba C, Malendowicz LK, Nussdorfer GG. Stimulatory effect of vasoactive intestinal peptide (VIP) on the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Biomed Res 1987;8:19–23.

    CAS  Google Scholar 

  • Mazzocchi G, Malendowicz LK, Meneghelli V, Gottardo G, Nussdorfer GG. Vasoactive intestinal polupeptide (VIP) stimulates hormonal secretion of the rat adrenal cortex in vitro: evidence that adrenal chromaffin cells are involved in the mediation of the mineralocorticoid but not glucocorticoid secretagogue action of VIP. Biomed Res 1993;14:435–440.

    CAS  Google Scholar 

  • Mazzocchi G, Malendowicz LK, Nussdorfer GG. Stimulatory effect of vasoactive intestinal peptide (VIP) on the secretory activity of dispersed rat adrenocortical cells: evidence for the interaction of VIP with ACTH receptors. J Steroid Biochem Mol Biol 1994;48:507–510.

    Article  PubMed  CAS  Google Scholar 

  • Mazzocchi G, Gottardo G, Nussdorfer GG. Pituitary adenylate cyclase-activating peptide enhances steroid production by interrenal glands in fowls: evidence for an indirect mechanism of action. Horm Metab Res 1997a;29:86–87.

    Article  CAS  Google Scholar 

  • Mazzocchi G, Gottardo G, Nussdorfer GG. Catecholamines stimulate steroid secretion of dispersed fowl adrenocortical cells, acting through the 0-receptor subtype. Horm Metab Res 1997b;29:190–192.

    Article  CAS  Google Scholar 

  • Mazzocchi G, Rebuffat P, Gottardo G, Nussdorfer GG. Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathway. Horm Metab Res 1998;30:241–243.

    Article  PubMed  CAS  Google Scholar 

  • MacKenzie CJ, Lutz EM, Johnson MS, Robertson DN, Holland PJ, Mitchell R. Mechanisms of phospholipase C activation by the vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide type 2 receptor. Endocrinology 2001;142:1209–1217.

    Article  PubMed  CAS  Google Scholar 

  • Moller K, Sundler F. Expression of pituitary adenylate cyclase-activating peptide (PACAP) and PACAP type I receptors in the rat adrenal medulla. Regul Pept 1996;63:129–139.

    Article  PubMed  CAS  Google Scholar 

  • Neri G, Andreis PG, Prayer-Galetti T, Rossi GP, Malendowicz LK, Nussdorfer GG. Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines. J Clin Endocrinol Metab 1996;81:169–273.

    Article  PubMed  CAS  Google Scholar 

  • Nilsson SF. PACAP-27 and PACAP-38: vascular effects in the eye and some other tissues in the rabbit. Eur J Pharmacol 1994;21:17–25.

    Article  Google Scholar 

  • Nogi H, Hashimoto H, Fujita T, Hagihara N, Matsuda T, Baba A. Pituitary adenylate cyclaseactivating polypeptide (PACAP) receptor mRNA in the rat adrenal gland; localization by in situ hybridization and identification of splice variants. Jpn J Pharmacol 1997;75:203–208.

    Article  PubMed  CAS  Google Scholar 

  • Nowak M, Markowska A, Nussdorfer GG, Tortorella C, Malendowicz LK. Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist. Neuropeptides 1994;27:297–303.

    Article  PubMed  CAS  Google Scholar 

  • Nowak KW, Neri G, Nussdorfer GG, Malendowicz LK. Comparison of the effects of VIP and PACAP on steroid secretion of dispersed rat adrenocortical cells. Biomed Res 1999;20:127–132.

    CAS  Google Scholar 

  • Nussdorfer GG. Cytophysiology of the adrenal cortex. Int Rev Cytol 1986;98:1–405.

    Article  PubMed  CAS  Google Scholar 

  • Nussdorfer GG, Mazzocchi G. Vasoactive intestinal peptide (VIP) stimulates aldosterone secretion by rat adrenal gland in vivo. J Steroid Biochem 1987;26:203–205.

    Article  PubMed  CAS  Google Scholar 

  • Nussdorfer GG. Paracrine control of adrenal cortical function by medullary chromaffin cells. Pharmacol Rev 1996;48:495–530.

    PubMed  CAS  Google Scholar 

  • Nussdorfer GG, Malendowicz LK. Role of VIP, PACAP, and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis. Peptides 1998;19:1443–1467.

    Article  PubMed  CAS  Google Scholar 

  • Oka H, Jin L., Reubi JC, Qian X, Scheithauer BW, Fuji K, Kameya T, Lloyd RV. Pituitary adenylate cyclase-activating polypeptide (PACAP) binding sites and PACAP/vasoactive intestinal polypeptide receptor expression in human pituitary adenomas. Am J Pathol 1998;153:1787–1796.

    Article  PubMed  CAS  Google Scholar 

  • Osipenko ON, Barrie AP, Allen JM, Gurney AM. Pituitary adenylyl cyclase-activating peptide activates multiple intracellular signaling pathways to regulate ion channels in PC12 cells. J Biol Chem 2000;275:16626–16631.

    Article  PubMed  CAS  Google Scholar 

  • Rebuffat P, Nowak KW, Tortorella C, Musajo FG, Gottardo G, Mazzocchi G, Nussdorfer GG. Evidence that endogenous vasoactive intestinal peptide (VIP) plays a role in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. J Steroid Biochem Mol Biol 1994;51:81–88.

    Article  PubMed  CAS  Google Scholar 

  • Robberecht P, Vertongen P, Langer I and Perret J. Developement of selective ligands for PAC1, VPACI and VPAC2 receptors. In Pituitary Adenylate Cyclase-Activating Polypeptide, Vaudry H and Arimura A, eds. Boston: Kluwer Academic Publishers 2002;pp49–67.

    Google Scholar 

  • Sasaki A, Sato S, Go M, Murakami 0, Hanew K, Yoshinaga K. Potentiation of peptide histidine methionine (PHM) on corticotropin-releasing hormone (CRH) induced ACTH secretion in humans. J Clin Endocrinol Metab 1987;65:1305–1307.

    Article  PubMed  CAS  Google Scholar 

  • Sherwood NM, Krueckl SL, McRory JE. The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)glucagon superfamily. Endocr Rev 2000;21:619–670.

    Article  Google Scholar 

  • Shiotani Y, Kimura S, Ohshige Y, Yanaihara C, Yanaihara N. Immunohistochemical localization of pituitary adenylate cyclase-activating polypeptide (PACAP) in the adrenal medulla of the rat. Peptides 1995;16:1045–1050.

    Article  PubMed  CAS  Google Scholar 

  • Shivers BD, Gores TJ, Gottschall PE, Arimura A. Two high-affinity binding sites for pituitary adenylate cyclase-activating polypeptide have different tissue distributions. Endocrinology 1991;128:3055–3065.

    Article  PubMed  CAS  Google Scholar 

  • Spengler D, Waeber C, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, Journot I. Differential signal transduction by five splice variants of the PACAP receptor. Nature 1993;365:170–175.

    Article  PubMed  CAS  Google Scholar 

  • Tabarin A, Chen D, Hakkanson R, Sundler F. Pituitary adenylate cyclase-activating peptide in the adrenal gland of mammals: distribution, characterization, and responses to drugs. Neuroendocrinology 1994;59:113–119.

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Totsune K, Murakami 0, Sone M, Itoi K, Miura Y, Mouri T. Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in pheochromocytomas. Peptides 1993;14:365–369.

    Article  PubMed  CAS  Google Scholar 

  • Tamakawa H, Miyata A, Satoh K, Miyake Y, Matsuo H, Arimura A, Kangawa K. The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats. Peptides 1998;19:1497–1502.

    Article  PubMed  CAS  Google Scholar 

  • Tanaka K, Shibuya I, Uezono Y, Ueta Y, Toyohira Y, Yanagihara N, Izumi F, Kanno T, Yamashita H. Pituitary adenylate cyclase-activating polypeptide causes Calf release from ryanodine/caffeine stores through a novel pathway independent of both inositol trisphosphates and cyclic AMP in bovine adrenal medullary cells. J Neurochem 1998;70:1652–1661.

    Article  PubMed  CAS  Google Scholar 

  • Taupenot L, Mahata SK, Wu H, O’Connor DT. Peptidergic activation of transcription and secretion in chromaffin cells. cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP). J Clin Invest 1998;101:863–876.

    Article  PubMed  CAS  Google Scholar 

  • Taupenot L, Mahata M, Mahata SK, O’Connor DT. Time-dependent effects of neuropeptide PACAP on catecholamine secretion. Stimulation and desensitization. Hypertension 1999;34:1152–1162.

    Article  PubMed  CAS  Google Scholar 

  • Tornoe K, Hannibal J, Borglum-Jensen T, Georg B, Fledelius-Rickelt L, Bolding-Andreasen M, Fahrenkrug J, Hoist JJ. PACAP(1–38) as neurotransmitter in the porcine adrenal glands. Am J Physiol 2000;279:E1413–E1425.

    CAS  Google Scholar 

  • Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol Rev 2000;52:269–324.

    PubMed  CAS  Google Scholar 

  • Vinson GP, Hinson JP. Blood flow and hormone secretion in the adrenal gland. In: James VHT, ed. The Adrenal Gland. New York: Raven Press;1992:71–86.

    Google Scholar 

  • Vinson GP, Whitehouse BJ, Hinson JP. The Adrenal Cortex. Englewood Cliffs (NJ): Prentice Hall;1992.

    Google Scholar 

  • Watanabe T, Masuo Y, Matsumoto H, Suzuki N, Othaki T, Matsuda Y, Kitada C, Tsuda M, Fujino M. Pituitary adenylate cyclase-activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline. Biochem Biophys Res Commun 1992;182:403–411.

    Article  PubMed  CAS  Google Scholar 

  • Watanobe H, Tamura T. Stimulation by peptide histidine methionine (PHM) of adrenocorticotropin secretion in patients with Cushing’s disease: a comparison with the effect of vasoactive intestinal peptide (VIP) and a study on the effect of combined administration of corticotropin-releasing hormone with PHM or VIP. J Clin Endocrinol Metab 1994;78:1372–1377.

    Article  PubMed  CAS  Google Scholar 

  • Yon L, Feuilloley M, Chartrel N, Arimura A, Fournier A, Vaudry H. Localization, characterization, and activity of pituitary adenylate cyclase-activating polypeptide in the frog adrenal gland. J Endocrinol 1993;139:183–194.

    Article  PubMed  CAS  Google Scholar 

  • Yon L, Chartrel N, Feuilloley M, De Marchis S, Fournier A, De Rijk E, Pelletier G, Roubos E, Vaudry H. Pituitary adenylate cyclase-activating polypeptide stimulates both adrenocortical cells and chromaffin cells in the frog adrenal gland. Endocrinology 1994;135:2749–2758.

    Article  PubMed  CAS  Google Scholar 

  • Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N. Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation. J Clin Endocrinol Metab 1998;83:1299–1305.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Human Anatomy and Physiology, University of Padua, Via Gabelli 65, Padua, Italy

    G. G. Nussdorfer

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  1. G. G. Nussdorfer
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  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Nussdorfer, G.G. (2003). Function of PACAP in the Adrenal Cortex. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_9

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  • DOI: https://doi.org/10.1007/978-1-4615-0243-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4983-9

  • Online ISBN: 978-1-4615-0243-2

  • eBook Packages: Springer Book Archive

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