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Consequences of PACAP Gene Knockout

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Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

PACAP is considered to be an important neuropeptide not only because the structure is tightly conserved in evolution, but also because PACAP is known to increase cAMP in many tissues (Sherwood et al, 2000). However, the multiplicity of PACAP receptors and target tissues suggests that either PACAP is released due to a major event such as environmental or metabolic stress, which results in a PACAP-coordinated response or PACAP has a plethora of functions that can be activated by local stimuli resulting in paracrine events. One approach in understanding the role of PACAP in vivo is to knockout the PACAP gene by targeted disruption in the mouse. This approach can reveal whether PACAP is essential or is compensated by other hormones and whether PACAP is necessary during embryogenesis or thereafter.

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Author information

Authors and Affiliations

  1. University of Victoria Victoria, British Columbia, V8W 2Y2, Canada

    N. M. Sherwood, S. L. Gray & K. J. Cummings

Authors
  1. N. M. Sherwood
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  2. S. L. Gray
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  3. K. J. Cummings
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Editor information

Editors and Affiliations

  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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© 2003 Springer Science+Business Media New York

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Sherwood, N.M., Gray, S.L., Cummings, K.J. (2003). Consequences of PACAP Gene Knockout. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_16

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  • DOI: https://doi.org/10.1007/978-1-4615-0243-2_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4983-9

  • Online ISBN: 978-1-4615-0243-2

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