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Function of PACAP in the Respiratory System

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Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

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Abstract

Since the discovery of the activity of vasoactive intestinal peptide (VIP) as a vasodilator peptide in the lung (Said, 1967) and its subsequent isolation from the small intestine (Said and Mutt, 1970), a rich array of studies has characterized the presence and/or the regulatory role of many other neuropeptides in the respiratory system (Boonsma and Said, 1992; Said, 1995; Maggi et al, 1995; Van der Velden et al, 1999). The observation of the potent anti-asthma and anti-inflammatory effects of VIP in the lung and airways was confirmed with other VIP-related peptides that possess common mechanisms of action (Said, 1992; Maggi et al, 1995).

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  1. University of Alcalá, Campus Universitario, Alcalá de Henares, Spain

    J. C. Prieto

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  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Prieto, J.C. (2003). Function of PACAP in the Respiratory System. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_13

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