Abstract
Leukotrienes and prostaglandins, derived from the oxidative metabolism of arachidonic acid1’2are potent lipid mediators of tissue inflammation.3’4The first step in the generation of these eicosanoids, is the liberation of esterified arachidonic acid from the sn-2 position of cell membrane glycerophospholipids by the action of phospholipase A2 (PLA2)5. The family of mammalian PLA2enzymes includes the 85-kDa group IV cytosolic PLA2(cPLA2); at least eight low molecular weight, cysteine-rich PLA2enzymes; and calcium-independent species of PLA2.6
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Diaz, B.L., Fujishima, H., Sapirstein, A., Bonventre, J.V., Arm, J.P. (2002). Participation of Cytosolic Phospholipase A2 in Eicosanoid Generation by Mouse Bone Marrow-Derived Mast Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_7
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DOI: https://doi.org/10.1007/978-1-4615-0193-0_7
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