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Biological, Physical, and Chemical Properties of Fish Oil and Industrial Applications

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Seafood Processing By-Products

Abstract

In the recent past, there has been an increasing demand for fish oil in the pharmaceutical industry, due to the findings of the health benefits provided by omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fish oils are unique in the variety of fatty acids of which they are composed, and are an excellent source of the highly unsaturated C20 and C22 omega-3 fatty acids of medical interest. In the past, fish oil was mainly used as an important ingredient in aquaculture feeds and was also used in feeds for livestock, such as poultry and swine. Due to increasing awareness on the potential health beneficial roles of omega-3 fatty acids in humans, there has been an increasing interest in the use of fish oils for human consumption. The nutritional and physical properties of fish oil have made hardened fish oils an attractive constituent in the human diet. A wide range of food products containing fish oils have been launched over the past decade. The instability of EPA and DHA and the fishy odor have become major problems in incorporating long-chain omega-3 oils into food products. There is an established market for dietary supplements, as well as a developing market for food ingredients produced from fish oils and concentrates of fish oil. Increasing scientific evidence in the health beneficial roles of fish oil has led to a tremendous growth in its use in the pharmaceutical industry and it is expected to play a dominant role in the future.

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References

  • Aidos I (2002) Production of high-quality fish oil from herring byproducts. Ph. thesis, Wageningen University, The Netherlands

    Google Scholar 

  • Ajiro K, Sawamura M, Ikeda K, Nara Y, Nishimura M, Ishida H, Seino Y, Yamori Y (2000) Beneficial effects of fish oil on glucose metabolism in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 27(5–6):412–415

    Article  CAS  Google Scholar 

  • Arterburn LM, Boswell KD, Koskelo EK, Kassner SL, Kelly C, Kyle DJ (2000) A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO® oil). Food Chem Toxicol 38(1):35–49

    Article  CAS  Google Scholar 

  • Ashton I, Clements K, Barrow SE, Secombes CJ, Rowley AF (1994) Effects of dietary fatty acids on eicosanoid-generating capacity, fatty acid composition and chemotactic activity of rainbow trout (Oncorhynchus mykiss) leucocytes. Biochim Biophys Acta 1214(3):253–262

    Article  Google Scholar 

  • Barascu A, Besson P, Le Floch O, Bougnoux P, Jourdan M-L (2006) CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells. Int J Biochem Cell Biol 38(2):196–208

    Article  CAS  Google Scholar 

  • Barlow SM, Young FVK (1988) New uses for fish oils. Food manufacture, Oct 1988, 75 pp

    Google Scholar 

  • Belch JJF, Muir A (1998) n-6 and n-3 essential fatty acids in rheumatoid arthritis and other rheumatic conditions. Proc Nutr Soc 57:563–569

    Article  CAS  Google Scholar 

  • Bimbo AP (1989) Fish oils: past and present food uses. J Am Oil Chem Soc 66:1717–1726

    Article  CAS  Google Scholar 

  • Bimbo AP (1990) In the USA. Oils Fats Int 4:46–49

    Google Scholar 

  • Bimbo AP (1997) Menhaden oil: the GRAS petition from hell. Inform 8:1069–1075

    Google Scholar 

  • Bimbo AP (1998) Guidelines for characterizing food-grade fish oils. Inform 9:473–483

    Google Scholar 

  • Bimbo AP (2005) Rendering. In: Shahidi F (ed) Bailey’s industrial oil and fat products, 6th edn. Wiley, Hoboken, pp 57–102

    Google Scholar 

  • Bimbo AP, Crowther JB (1991) Fish oils: processing beyond crude oil. Infofish Int 6:20–25

    Google Scholar 

  • Bose AN, Ghosh SN, Yang CT, Mitra A (1991) Coastal aquaculture engineering. Chapman and Hall, New York, 361 pp

    Google Scholar 

  • Bougnoux P (1999) n-3 polyunsaturated fatty acids and cancer. Curr Opin Clin Nutr Metab Care 2:121–126

    Article  CAS  Google Scholar 

  • Calviello G, Palozza P, Piccioni E, Maggiano N, Frattucci A, Franceschelli P, Bartoli GM (1998) Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. Int J Cancer 75:699–705

    Article  CAS  Google Scholar 

  • Connor WE (2000) Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 71:171S–175S

    CAS  Google Scholar 

  • Coutteau P, Ceulemans S, Halteren AV, Robles R (2002) Fishmeal and fish oil in aquafeeds. Int Aquafeed Dir Buy Guide 2002:20–24

    Google Scholar 

  • Damude HG, Kinney AJ (2008) Engineering oilseeds to produce nutritional fatty acids. Physiol Plant 132(1):1–10

    CAS  Google Scholar 

  • Das S, Paul BN, Sengupta J, Datta AK (2009) Beneficial effects of fish oil to human health: a review. Agr Rev 30(3):199–205

    Google Scholar 

  • Deutch B (1995) Menstrual pain in Danish women correlated with low n-3 polyunsaturated fatty acid intake. Eur J Clin Nutr 49:508–516

    CAS  Google Scholar 

  • Dewsbury CE, Graham P, Darley CR (1989) Topical eicosapentaenoic acid (EPA) in the treatment of psoriasis. Br J Dermatol 120(4):581–584

    Article  CAS  Google Scholar 

  • EFSA Panel on Biological Hazards (BIOHAZ) (2010) Scientific opinion on fish oil for human consumption. Food hygiene, including rancidity. EFSA J 8(10):1874 (48 pp)

    Google Scholar 

  • FAO (1986) FAO Fisheries department, fishery industries division, food and agriculture organization of the United Nations. The production of fish meal and oil. FAO Fisheries Technical Paper No. 142, Chapter 1, Via delle Terme di Caracalla, Rome, Italy

    Google Scholar 

  • FAO (2002) Fisheries statistics, FAO. http://www.fao.org

  • FAO (2003) Globefish: fishmeal and fish oil update. FAO, Rome

    Google Scholar 

  • FAO (2008) FAO fisheries department, fishery information, data and statistics unit. FishStat Plus: universal software for fishery statistical time series. Aquaculture production: quantities 1950–2006; aquaculture production: values 1984–2006; capture production: 1950–2006; commodities production and trade: 1950–2006; total production: 1970–2006. Version. 2.30

    Google Scholar 

  • FAO (2010) Fisheries and aquaculture department, fishery statistical collections, fishery commodities and trade. http://www.fao.org/fishery/statistics/global-commodities-production/en. Accessed 14 Oct 2010

  • Food and Agriculture Organization (FAO) (2009) FishStat Plus: universal software for fishery statistical time series

    Google Scholar 

  • Fishmeal Information Network (FIN) (2010) Fishmeal and fish oil figures, p. 4, [http://www.gafta.com/fin/pdfs/FACTSANDFIGURES.pdf]

  • Gallai V, Sarchielli P, Trequattrini A, Franceschini M, Floridi A, Firenze C, Alberti A, Di Benedetto D, Stragliotto E (1995) Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. J Neuroimmunol 56:143–153

    Article  CAS  Google Scholar 

  • Garcia DJ (1998) Omega-3 long chain PUFA nutraceuticals. Food Technol 52:44–49

    Google Scholar 

  • Heller JH, Heller MS, Springer S, Clarke E (1957) Squalene content of various shark livers. Nature 179:919–920

    Article  CAS  Google Scholar 

  • Holman RT (1998) The slow discovery of the importance of omega 3 essential fatty acids in human health. J Nutr 128(2S):427S–433S

    CAS  Google Scholar 

  • Horrocks LA, Yeo YK (1999) Health benefits of docosahexaenoic acid (DHA). Pharmacol Res 40:211–225

    Article  CAS  Google Scholar 

  • IFFO (2001) International Fishmeal and Fish Oil Organization. Fishmeal and oil – supplies and markets. Presentation to ground fish forum. http://www.iffo.org.uk/Supplies.pdf. Oct 2001

  • Innis SM (2007) Dietary (n-3) fatty acids and brain development. J Nutr 137:855–859

    CAS  Google Scholar 

  • Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S (2006) Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese. Circulation 113(2):195–202

    Article  CAS  Google Scholar 

  • Jackson AJ (2007) Challenges and opportunities for the fishmeal and fish oil industry. Feed Technol Update 2:3–11

    Google Scholar 

  • Jangaard PM (1986) Report no. 115, Program development, Fisheries Branch, Halifax, Nova Scotia

    Google Scholar 

  • Jiang WG, Bryce RP, Horrobin DF (1998) Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Crit Rev Oncol Hematol 27(3):179–209

    Article  CAS  Google Scholar 

  • Kris-Etherton PM, Harris WS, Appel LJ (2003) Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 23:151–152

    CAS  Google Scholar 

  • Kroes R, Schaefer EJ, Squire RA, Williams GM (2003) A review of the safety of DHA45-oil. Food Chem Toxicol 41(11):1433–1446

    Article  CAS  Google Scholar 

  • Kumar KV, Rao SM, Gayani R, Mohan IK, Naidu MUR (2000) Oxidant stress and essential fatty acids in patients with risk and established ARDS. Clin Chim Acta 298:111–120

    Article  CAS  Google Scholar 

  • Lai PB, Ross JA, Fearon KC, Anderson JD, Carter DC (1996) Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br J Cancer 74(9):1375–1383

    Article  CAS  Google Scholar 

  • Lambertsen G, Holman RT (1963) Partial characterization of the hydrocarbons of herring oil. Acta Chem Scand 17:281–282

    Article  CAS  Google Scholar 

  • Mahéo K, Vibet S, Steghens JP, Dartigeas C, Lehman M, Bougnoux P, Goré J (2005) Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. Free Radic Biol Med 39:742–751

    Article  Google Scholar 

  • Mangold HK, Malins DC (1960) Fractionation of fats, oils, and waxes on thin layers of silicic acid. J Am Oil Chem Soc 37(8):383–385

    Article  CAS  Google Scholar 

  • McHugh MA, Krukonis VJ (1986) Supercritical fluid extraction: principles and practice. Butterworth-Heinemann, Stoneham, MA. 1st edn Apr 1986. 2nd edn, Jan 1994, 512 pp

    Google Scholar 

  • Miller MR, Nichols PD, Carter CG (2008) n-3 Oil sources for use in aquaculture – alternatives to the unsustainable harvest of wild fish. Nutr Res Rev 21(2):85–96

    Article  CAS  Google Scholar 

  • Mori TA, Beilin LJ, Burke V, Morris J, Ritchie J (1997) Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. Arterioscler Thromb Vasc Biol 17:279–286

    CAS  Google Scholar 

  • Moyad MA (2005) An introduction to dietary/supplemental omega-3 fatty acids for general health and prevention: part II. Urol Oncol Semin Orig Invest 23:36–48

    Article  CAS  Google Scholar 

  • Mozaffarian D, Rimm EB (2006) Fish intake, contaminants, and human health: evaluating the risks and the benefits. J Am Med Assoc 296(15):1885–1899

    Article  CAS  Google Scholar 

  • Navarro-García G, Pacheco-Aguilar R, Bringas-Alvarado L, Ortega-García J (2004) Characterization of the lipid composition and natural antioxidants in the liver oil of Dasyatis brevis and Gymnura marmorata rays. Food Chem 87:89–96

    Article  Google Scholar 

  • Newton IS (1996) Food enrichment with long chain n-3 polyunsaturated fatty acids. Inform 7:169–177

    Google Scholar 

  • Olsen Y, Otterstad O, Duarte CM (2008) Status and future perspectives of marine aquaculture. In: Holmer M, Black K, Duarte CM, Marbà N, Karakassis I (eds) Aquaculture in the ecosystem. Springer, Berlin

    Google Scholar 

  • Opstvedt J (1985) Fish lipids in animal nutrition. IAFMM Technical Bulletin 22, International Association of Fish Meal Manufacturers, Hoval House, Mutton Lane, Potters Bar, Hertfordshire EN6, 3AR, UK

    Google Scholar 

  • Patterson CA (2008) Omega-3 fatty acids (marine derived) essential to human health. Agriculture and Agri-Food Canada. http://www.agr.gc.ca. Aug 2008

  • Pike IH (2005) Eco-efficiency in aquaculture: global catch of wild fish used in aquaculture. Int Aquafeed 8:38–40

    Google Scholar 

  • Pike IH, Barlow SM (2003) Impact of fish farming on fish stocks. Fish Farm 26(1):14–16

    Google Scholar 

  • Pike IH, Jackson A (2010) Fish oil: production and use now and in the future. Lipid Technol 22(3):59–61

    Article  CAS  Google Scholar 

  • Piñeiro CG, Casas M, Bañón R (2001) The deep-water fisheries exploited by Spanish fleets in the Northeast Atlantic: a review of the current status. Fish Res 51:311–320

    Article  Google Scholar 

  • Psota TL, Gebauer SK, Kris-Etherton P (2006) Dietary omega-3 fatty acid intake and cardiovascular risk. Am J Cardiol 98(4A):3i–18i

    Article  CAS  Google Scholar 

  • Rowland GG, McHughen A, Bhatty RS, MacKenzie SL, Taylor DC (1995) The application of chemical mutagenesis and biotechnology to the modification of linseed (Linum usitatissimum L.). Euphytica 85(1–3):317–321

    Article  CAS  Google Scholar 

  • Schrooyen PMM, van der Meer R, De Kruif CG (2001) Microencapsulation: its application in nutrition. Proc Nutr Soc 60:475–479

    Article  CAS  Google Scholar 

  • Severus WE, Ahrens B, Stoll AL, Nemeroff CB (1999) Omega-3 fatty acids – the missing link? Arch Gen Psychiat 56:380–381

    Article  CAS  Google Scholar 

  • Shepherd CJ, Pike IH, Barlow SM (2005) Sustainable feed resources of marine origin. European Aquaculture Society Special Publication no. 35, Aquaculture Europe Jun 2005, pp 59–66

    Google Scholar 

  • Silk MH, De Koning AJ (1964) Phospholipids of the South African pilchard (Sardina ocellata Jenyns). J Am Oil Chem Soc 41:619–622

    Article  CAS  Google Scholar 

  • Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54:438–463

    CAS  Google Scholar 

  • Sinclair AJ, Begg D, Mathai M, Weisinger RS (2007) Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac J Clin Nutr 16:391–397

    CAS  Google Scholar 

  • Stark KD, Park EJ, Maines VA, Holub BJ (2000) Effect of a fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial. Am J Clin Nutr 72(2):389–394

    CAS  Google Scholar 

  • Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, Pascoe WS (1987) Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237(4817):885–888

    Article  CAS  Google Scholar 

  • Turchini GM, Torstensen BE, Ng WK (2009) Fish oil replacement in finfish nutrition. Rev Aquac 1:10–57

    Article  Google Scholar 

  • Uauy R, Valenzuela A (2000) Marine oils: the health benefits of n-3 fatty acids. Nutrition 16:680–684

    Article  CAS  Google Scholar 

  • van der Schacky C (2000) n-3 fatty acids and the prevention of coronary atherosclerosis. Am J Clin Nutr 71:224s–227s

    Google Scholar 

  • Wirth M et al (1992) Symposium on omega-3 fatty acids: metabolism and biological effects. 15–19 Sept 1992, Oslo, Norway Abst. 158

    Google Scholar 

  • Yazawa K (2001) Recent development of health foods enriched with DHA, EPA and DPA in Japan. World Rev Nutr Diet 88:249–252

    Article  CAS  Google Scholar 

  • Young FVK (1986) The chemical properties of crude fish oils for refiners and hydrogenators. Fish Oil Bulletin No. 18, June 1986

    Google Scholar 

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Authors and Affiliations

  1. Department of Food Science and Technology, University of Peradeniya, Peradeniya, Sri Lanka

    V. Rizliya & Eresha Mendis

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  1. V. Rizliya
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  2. Eresha Mendis
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Correspondence to V. Rizliya .

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  1. Specialized Graduate School of Convergence Science and Technology, Department of Marine-bio Convergence Science, Marine Bioprocess Research Center, Pukyong National University, Nam-GU, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Rizliya, V., Mendis, E. (2014). Biological, Physical, and Chemical Properties of Fish Oil and Industrial Applications. In: Kim, SK. (eds) Seafood Processing By-Products. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9590-1_14

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