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Association Between Oxidative Stress and Periodontal Diseases in Animal Model Studies

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Studies on Periodontal Disease

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Abstract

Animal models have contributed new knowledge to biological sciences, including periodontology. Rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontal disease is commonly induced by placing a bacterial plaque-retentive ligature, by inoculation or injection of human oral bacteria (e.g., Porphyromonas gingivalis), or by applying virulence factors, such as lipopolysaccharide. A number of animal models of periodontitis support the notion that reactive oxygen species play a critical role in periodontitis. In this chapter, we summarize the characteristics of each animal model, their advantages, and the association between oxidative stress and periodontitis in animal model studies.

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Acknowledgments

This work was supported by Grants-in-Aid for Scientific Research (25293427) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.

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Authors and Affiliations

  1. Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Manabu Morita, Daisuke Ekuni & Takaaki Tomofuji

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  1. Manabu Morita
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  2. Daisuke Ekuni
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  3. Takaaki Tomofuji
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Correspondence to Manabu Morita .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Morita, M., Ekuni, D., Tomofuji, T. (2014). Association Between Oxidative Stress and Periodontal Diseases in Animal Model Studies. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_3

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