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The Inflammation as the Connecting Link Between Systemic Diseases and Periodontal Diseases

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Studies on Periodontal Disease

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Abstract

Numerous epidemiological studies have found associations between periodontitis and systemic conditions, but there is a lack of consensus on the nature of the connecting link among them. This chapter shows the recent advances about systemic inflammatory markers in periodontitis patients, the effect of periodontal therapy over systemic inflammatory markers, and some putative pathogenic mechanisms that could be shared with other conditions. C-reactive protein has been the most studied marker, with increasing evidence of the effect of periodontal therapy on this one and other inflammatory markers, and the influence over the progression of the systemic condition. Cross-reactivity to Porphyromonas gingivalis heat shock proteins and citrullination of host proteins by this species are presented as mechanisms linking periodontal and systemic conditions, specially rheumatoid arthritis.

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Authors and Affiliations

  1. Área de Ciencias Básicas – Escuela Universitaria de Enfermería y Fisioterapia San Juan de Dios, Universidad Pontificia Comillas, Avda. San Juan de Dios 1, 28350, Ciempozuelos, Madrid, Spain

    Juan Manuel Morillo-Velázquez

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  1. Juan Manuel Morillo-Velázquez
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Correspondence to Juan Manuel Morillo-Velázquez .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Morillo-Velázquez, J.M. (2014). The Inflammation as the Connecting Link Between Systemic Diseases and Periodontal Diseases. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_12

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