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Fundamentals of Peptide-Materials Interfaces

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Bio-Inspired Nanotechnology

Abstract

The investigation of the binding, dynamics and properties of peptides adsorbed on inorganic surfaces is an inherently multidisciplinary endeavor. This chapter is primarily aimed at new researchers in this field, to introduce the basic concepts that span physical chemistry, surface science, structural biology, computational techniques, and materials science; all of which are necessary for gaining a comprehensive overview of peptide-materials interfaces. What are the key insights that can be determined from these interfaces? Usually, this will comprise a blend of thermodynamics, kinetics and structural characterizations. Typically, we might wish to compare the binding strength of a peptide, and concomitantly, the structure(s) assumed by the peptide upon adsorption. We might also seek to characterize the surface diffusion, and/or aggregation (or assembly) of these surface-adsorbed biomolecules. These observations serve to facilitate connections between the composition and sequence of the peptide, and its behavior and properties at the interface. Such connections could be subsequently exploited in bioinformatics models to enable the prediction of new peptide sequences, with designed, predictable interfacial properties.

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Acknowledgments

TRW gratefully recognizes the enormously valuable contributions from members of her research group past and present, who have worked in this research field: Dr. Adam Skelton, Dr. Taining Liang, Dr. Rebecca Notman, Dr. Susana Tomasio, Simon Friling, Louise Wright, Aaron Brown, Jasmine Desmond, Dr J. Pablo Palafox-Hernandez, Dr Zak Hughes, Kurt Drew, Anas Sultan and Andrew Church. TRW also acknowledges helpful discussions with colleagues and collaborators, from both experiment and theory, in the field of peptide-surface interactions: M. R. Knecht, R. R. Naik, R. A. Latour, J. S. Evans, S. Corni, L. Colombi-Ciacchi, S. Monti, M. Sarikaya, C. Tamerler, E. E. Oren, C. C. Perry, C. L. Freeman, P. M. Rodger, M. P. Allen, J. D. Gale, S. L. S. Stipp, J. H. Harding, M. T. Swihart and P. N. Prasad. Funding from the EPSRC, AFOSR, Deakin University and the AOARD is gratefully acknowledged. TRW thanks veski for an Innovation Fellowship.

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Authors and Affiliations

  1. Institute for Frontier Materials, Deakin University, Geelong, VIC, 3216, Australia

    Tiffany R. Walsh

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  1. Tiffany R. Walsh
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Correspondence to Tiffany R. Walsh .

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Editors and Affiliations

  1. Department of Chemistry, University of Miami, Coral Gables, Florida, USA

    Marc R. Knecht

  2. Institute for Frontier Materials, Deakin University, Geelong, Victoria, Australia

    Tiffany R. Walsh

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Walsh, T.R. (2014). Fundamentals of Peptide-Materials Interfaces. In: Knecht, M., Walsh, T. (eds) Bio-Inspired Nanotechnology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9446-1_2

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  • DOI: https://doi.org/10.1007/978-1-4614-9446-1_2

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