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In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines

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Nanotoxicology

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

One of the greatest interests in the pharmaceutical and cosmetic industries today is the promising of new substances without adverse effects. Preclinical animal safety investigations and clinical trials increase the time necessary to bring a new candidate compound to the market and increase development costs and time dispensed in this process. Cell culture models are adequate for screening toxicity of several substances including nanomaterials. The data from those models can provide an indication of the safety use of these particles in humans since they are proven hazardous.

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Acknowledgments

Supports from FAPESP, CNPq, INOMAT (MCTI/CNPq), NanoBioss (MCTI), and Brazilian Network on Nanotoxicology (MCTI/CNPq) are acknowledged.

Author information

Authors and Affiliations

  1. METROCAMP, Grupo Ibmec, Campinas, Sao Paulo, 13035-270, Brazil

    Patricia S. Melo

  2. Faculty of Pharmaceutical Sciences of Riberão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

    Priscyla D. Marcato

  3. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC – UFABC, Santo André, São Paulo, Brazil

    Daniele R. de Araújo

  4. Biological Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

    Nelson Durán

  5. Center of Natural and Human Sciences, Universidade Federal do ABC – UFABC, Santo André, São Paulo, Brazil

    Nelson Durán

Authors
  1. Patricia S. Melo
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  2. Priscyla D. Marcato
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  3. Daniele R. de Araújo
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  4. Nelson Durán
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Corresponding author

Correspondence to Patricia S. Melo .

Editor information

Editors and Affiliations

  1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Nelson Durán

  2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Silvia S. Guterres

  3. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Oswaldo L. Alves

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Melo, P.S., Marcato, P.D., de Araújo, D.R., Durán, N. (2014). In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines. In: Durán, N., Guterres, S., Alves, O. (eds) Nanotoxicology. Nanomedicine and Nanotoxicology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8993-1_5

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