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Bridging the Gap Between Modeling of Tumor Growth and Clinical Imaging

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Abdomen and Thoracic Imaging

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Abstract

This chapter gives a brief overview of the biological processes involved in vascularized tumor growth, followed by a summary of recent mathematical modeling to simulate the biology of tumor growth and angiogenesis. It provides an overview of medical image analysis and describes recent efforts in the area of coupling such tumor models with imaging data. We do not discuss the research of obtaining tumor-specific information from medical imaging data, for which extensive work has been done in image processing and signal analysis. The chapter concludes with a sample simulation of vascularized tumor growth showing the critical role of vascularization in tumor invasiveness and highlighting the potential of gaining further insight into tumor behavior from a more expansive future integration of 3D tumor models with clinical imaging data.

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Authors and Affiliations

  1. Department of Electrical Engineering, University of Louisville, Louisville, KY, 40208, USA

    Behnaz Abdollahi Ph.D.

  2. Department of Radiation Oncology, University of Louisville, Louisville, KY, 40202, USA

    Neal Dunlap M.D., Ph.D.

  3. Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, KY, 40208, USA

    Hermann B. Frieboes Ph.D.

Authors
  1. Behnaz Abdollahi Ph.D.
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  2. Neal Dunlap M.D., Ph.D.
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  3. Hermann B. Frieboes Ph.D.
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Correspondence to Hermann B. Frieboes Ph.D. .

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Editors and Affiliations

  1. Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA

    Ayman S. El-Baz

  2. University of Cagliari, Cagliari, Italy

    Luca Saba

  3. Biomedical Technologies, Inc Idaho State University (Affiliated), Roseville, California, USA

    Jasjit Suri

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Abdollahi, B., Dunlap, N., Frieboes, H.B. (2014). Bridging the Gap Between Modeling of Tumor Growth and Clinical Imaging. In: El-Baz, A., Saba, L., Suri, J. (eds) Abdomen and Thoracic Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-8498-1_18

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