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CyberKnife

  • Chapter
Principles and Practice of Stereotactic Radiosurgery

Abstract

CyberKnife is a radiosurgery system composed of a linear accelerator mounted on a robotic arm coupled with an X-ray imaging device that is capable of delivering high-precision radiotherapy. The robotic arm allows a wide array of noncoplanar beam angles that can produce a highly conformal dose distribution. While isocentric beam arrangements can be utilized for spherical targets, an additional function of CyberKnife is the ability to use non-isocentric beam angles, facilitating the treatment of irregularly shaped targets. Imaging with ceiling-mounted X-ray imagers allows for near real-time imaging adjustments to be made during treatment. The Synchrony™ tracking system and more recently XSight Lung provides the ability to correct for respiratory motion, with or without implanted fiducial markers. The submillimeter accuracy of CyberKnife ushered in widespread use of frameless radiosurgery, facilitating both multi-fractionation schedules and the treatment of extracranial lesions. CyberKnife has successfully been used in the treatment of tumors in the brain, spine, thorax, liver, prostate, kidney, and pancreas as well as other body sites with excellent results. In this chapter, we review the technological capabilities of the CyberKnife system, its clinical indications and outcomes, and future advancements and directions.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University, Stanford, CA, USA

    Carolina E. Fasola M.D., Lei Wang Ph.D., Scott G. Soltys M.D., Iris C. Gibbs M.D., Albert C. Koong M.D., Ph.D. & Daniel T. Chang M.D.

  2. Neurosurgery, Stanford University, Stanford, CA, USA

    John R. Adler M.D.

  3. Varian Medical Systems, Stanford, CA, USA

    John R. Adler M.D.

Authors
  1. Carolina E. Fasola M.D.
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  2. Lei Wang Ph.D.
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  3. John R. Adler M.D.
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  4. Scott G. Soltys M.D.
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  5. Iris C. Gibbs M.D.
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  6. Albert C. Koong M.D., Ph.D.
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  7. Daniel T. Chang M.D.
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Corresponding author

Correspondence to Daniel T. Chang M.D. .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, USA

    Lawrence S. Chin

  2. Dept. of Radiation Oncology, Univ. of Maryland School of Medicine, Baltimore, Maryland, USA

    William F. Regine

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© 2015 Springer Science+Business Media New York

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Fasola, C.E. et al. (2015). CyberKnife. In: Chin, L., Regine, W. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8363-2_11

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  • DOI: https://doi.org/10.1007/978-1-4614-8363-2_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8362-5

  • Online ISBN: 978-1-4614-8363-2

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