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Molecular Genetic Mechanisms of Axial Patterning: Mechanistic Insights into Generation of Axes in the Developing Eye

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Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

Abstract

All multicellular organisms require axial patterning to transform a single-layer organ primordium to a three-dimensional organ. It involves delineation of anteroposterior (AP), dorsoventral (DV), and proximodistal (PD) axes. Any deviation in this fundamental process results in patterning and growth defects during organogenesis. The Drosophila eye is an excellent model to study axial patterning. In the Drosophila eye, DV lineage is the first axis to be determined, which is followed by generation of the AP axis. The default state of the Drosophila early eye primordium is ventral, and the dorsal fate is established by onset of expression of dorsal eye fate selector pannier (pnr)in a group of cells on the dorsal eye margin. The boundary between dorsal and ventral compartments is the site for activation of Notch (N) signaling and is referred to as the equator. Activation of N signaling is crucial for initiating the cell proliferation and differentiation in the developing Drosophila eye imaginal disc. This chapter will focus on (a) how axial patterning occurs in the developing Drosophila eye, (b) how the developing eye field gets divided into dorsal and ventral cell populations, and (c) how DV patterning genes contribute toward the growth and patterning of the fly retina.

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Acknowledgements

The authors thank Erika Wittkorn, Timothy Cutler, and Aditi Singh for their help and comments on the manuscript. We apologize to all authors whose work could not be cited due to space limitations. AS is supported by a NIH grant (1R15 HD064557–01), start-up support from the University of Dayton.

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  1. Department of Biology, University of Dayton, Dayton, OH, 45469, USA

    Meghana Tare, Oorvashi Roy Puli & Amit Singh

  2. Premedical Program, University of Dayton, Dayton, OH, 45469, USA

    Amit Singh

  3. Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, 45469, USA

    Amit Singh

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  1. Meghana Tare
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  2. Oorvashi Roy Puli
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Correspondence to Amit Singh .

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  1. Department of Biology, University of Dayton, Dayton, Ohio, USA

    Amit Singh

  2. Department of Biology Office: SC303C, University of Dayton, Dayton, Ohio, USA

    Madhuri Kango-Singh

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Tare, M., Roy Puli, O., Singh, A. (2013). Molecular Genetic Mechanisms of Axial Patterning: Mechanistic Insights into Generation of Axes in the Developing Eye. In: Singh, A., Kango-Singh, M. (eds) Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8232-1_2

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