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Polymer- and Lipid-Based Systems for Parenteral Drug Delivery

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Sterile Product Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 6))

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Abstract

The field of drug delivery technology research has continued to grow in recent decades, expanding from technologies traditionally focused on controlled release to now include nanotechnologies and functionalized molecular architectures for target-specific delivery. While these emerging novel technologies are beginning to mature, many of the clinical applications of controlled-release drug delivery technologies continue to focus on well-characterized biodegradable polymer particles, in situ forming gel depots, and lipid-based particulate formulations. This review principally focuses on the physicochemical and functional characteristics of in situ forming semisolid depot formulations and lipid-based drug delivery technologies and also discusses the broader considerations in bringing drug delivery-enabled products to market.

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Author information

Authors and Affiliations

  1. Biotherapeutics Pharmaceutical Sciences, Pfizer, Inc., Andover, MA, USA

    David Chen

  2. Parenteral Formulation Sciences, Millennium: The Takeda Oncology Company, Cambridge, MA, USA

    Sara Yazdi

Authors
  1. David Chen
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  2. Sara Yazdi
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Corresponding author

Correspondence to David Chen .

Editor information

Editors and Affiliations

  1. Pharmaceutical R&D-BioTx Pharmaceutical, Chesterfield, Missouri, USA

    Parag Kolhe

  2. LifeCell Corporation, Bridgewater, New Jersey, USA

    Mrinal Shah

  3. Drug Product Engineering, Amgen, Thousand Oaks, California, USA

    Nitin Rathore

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© 2013 American Association of Pharmaceutical Scientists

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Chen, D., Yazdi, S. (2013). Polymer- and Lipid-Based Systems for Parenteral Drug Delivery. In: Kolhe, P., Shah, M., Rathore, N. (eds) Sterile Product Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7978-9_3

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