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Role for Stearoyl-CoA Desaturase-1 in the Metabolic Effects of Leptin

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Stearoyl-CoA Desaturase Genes in Lipid Metabolism

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Abstract

The rising incidence in obesity has become a worldwide health epidemic. Obesity contributes to diabetes, cardiovascular disease, and a host of other metabolic abnormalities. The adipocyte-derived hormone leptin is the central signal in a negative feedback loop regulating appetite and energy homeostasis. Because most obese humans are leptin resistant, developing effective therapies for obesity will require a fuller understanding of the mechanism by which leptin regulates appetite and metabolism. Using a large screen we identified stearoyl-CoA desaturase-1 (SCD-1) as a prototypical leptin-regulated gene in the liver. Deletion of SCD-1 can partially correct the obesity, hypometabolic state, and hepatic steatosis associated with leptin deficiency. SCD-1 appears to be an important metabolic control point in the liver. When SCD-1 is repressed, fatty acid oxidation is promoted with accompanying metabolic benefits.

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Authors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Paul Cohen M.D., Ph.D.

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  1. Paul Cohen M.D., Ph.D.
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Correspondence to Paul Cohen M.D., Ph.D. .

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Editors and Affiliations

  1. Departments of Biochemistry and Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA

    James M. Ntambi, Ph.D.

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Cohen, P. (2013). Role for Stearoyl-CoA Desaturase-1 in the Metabolic Effects of Leptin. In: Ntambi, Ph.D., J. (eds) Stearoyl-CoA Desaturase Genes in Lipid Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7969-7_4

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