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Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers

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Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders

Abstract

The present chapter summarizes information on the pathophysiology of mood disorders and mechanisms of action of antidepressants and mood stabilizers with focus on an endocannabinoid regulation of monoamines in depression and bipolar disorder. Leading role in neurochemistry and pathophysiology of mood disorders could be awarded to disturbed monoamine neurotransmission, dysfunction in energy metabolism of neurons, modulation of inflammatory and neuroendocrine pathways, and changes in activities of transcription factors, neurotrophic factors and other components involved in neuroplasticity. A role of endocannabinoid system in pathophysiology of mood disorders is supposed, but little known. In the light of new findings, there is potential for pharmacological regulation of endocannabinoid system in treatment of depressive and bipolar disorder.

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Acknowledgment

This research was supported by project MSM0021620849 given by Ministry of Education, Youth and Sports, and by project PRVOUK-P26/LF1/4 given by Charles University in Prague, Czech Republic.

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  1. Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

    Zdeněk Fišar Ph.D.

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    Elisabeth J. Van Bockstaele

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Fišar, Z. (2013). Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers. In: Van Bockstaele, E. (eds) Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7940-6_6

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