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Arrhythmogenesis, Heart Failure, and the Biophysics of Z-Band Protein Networks

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Biophysics of the Failing Heart

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Cardiac function is determined by exquisite and finely tuned electromechanical activity of each myocyte, which in partnership with neighboring cells achieves a synchronized contraction and relaxation of the ventricular chambers to attain proper blood flow into systemic circulation. The complex cellular scaffold of each cardiomyocytes, the cytoskeleton (see also Chaps. 6 and 10), has been recently shown to be tightly associated with proteins forming channels, pores, and pumps that allow ions to move in and out the cellular barrier, and across different cells to provide the appropriate electrical stimulus throughout the heart. Here we consider some recent understanding of the connection between a subset of the cytoskeleton, the Z-band, and representative ion channels involved in the development of cardiac failure and arrhythmias.

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Author information

Authors and Affiliations

  1. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA

    M. Vatta

  2. Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, 60611, USA

    R. John Solaro

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  1. M. Vatta
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  2. R. John Solaro
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Correspondence to M. Vatta .

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Editors and Affiliations

  1. Dept. of Physiology & Biophysics, University of Illinois at Chicago, Chicago, USA

    R. John Solaro

  2. University of Arizona, Tucson, Arizona, USA

    Jil C. Tardiff

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Vatta, M., Solaro, R.J. (2013). Arrhythmogenesis, Heart Failure, and the Biophysics of Z-Band Protein Networks. In: Solaro, R., Tardiff, J. (eds) Biophysics of the Failing Heart. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7678-8_9

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