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Check Check and Double Check

Fatal Forty DDI: diazepam, fluvoxamine, CYP3A4, CYP2C19

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses the pharmacokinetic interaction between diazepam and fluvoxamine resulting in excessive sedation. Diazepam is a cytochrome P450 3A4 and 2C19 substrate and fluvoxamine is a cytochrome P450 3A4 and 2C19 inhibitor.

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References

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Authors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Psychiatry, University of Maryland Medical System, Baltimore, MD, USA

    Neil B. Sandson MD

  3. Department of Psychiatry, VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

Authors
  1. Catherine Marcucci MD
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  2. Neil B. Sandson MD
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Corresponding author

Correspondence to Catherine Marcucci MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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Marcucci, C., Sandson, N.B. (2015). Check Check and Double Check. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_83

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_83

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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