Abstract
This case discusses the pharmacokinetic interaction between methysergide and erythromycin resulting in vasospasm. Methysergide is a cytochrome P450 3A4 substrate and erythromycin is a 3A4 inhibitor.
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Abbreviations
- CYP:
-
cytochrome P450
- 5-HT:
-
5-hydroxytryptamine
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Lorenz, J.D., Sprung, J., Nicholson, W.T. (2015). My Headache Is Gone, But My Leg Now Hurts. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_67
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