Abstract
This case discusses the interaction of nortriptyline and paroxetine. Nortriptyline is a tricyclic antidepressant (TCA) that is a cytochrome P450 2D6 substrate and paroxetine is a 2D6 inhibitor. The interaction resulted in TCA toxicity. The metabolism of other TCAs is discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Leucht S, Hackl HJ, Steimer W, et al. Effect of adjunctive paroxetine on serum levels and side-effects of tricyclic antidepressants in depressive inpatients. Psychopharmacology (Berl). 2000;147(4):378–83.
Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999;39(6):567–77.
Olesen OV, Linnet K. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997;25:740–4.
A new antidepressant of the tricyclic group: nortriptyline hydrochloride (aventyl hydrochloride). JAMA. 1965;194:727–8.
Crewe HK, Lennard MS, Tucker GT, et al. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br J Clin Pharmacol. 1992;34:262–5.
von Moltke LL, Greenblatt DJ, Court MH, et al. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. J Clin Psychopharmacol. 1995;15(2):125–31.
Bertilsson L. Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects. Clin Pharmacol Ther. 2007;82:606–9.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Liu, S.S., Weingarten, T.N., Marcucci, C. (2015). Pining for Pete in the Pain Clinic. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_65
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7495-1_65
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7494-4
Online ISBN: 978-1-4614-7495-1
eBook Packages: MedicineMedicine (R0)