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Dad’s Not Having Much Pain

Fatal Forty DDI: methadone, ciprofloxacin, CYP3A4

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses a pharmacokinetic interaction between methadone and ciprofloxacin resulting in increased sedative and analgesic effects of methadone. Methadone is a cytochrome P450 3A4 substrate and ciprofloxacin is a 3A4 inhibitor.

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References

  1. Iribarne C, Berthou F, Baird S, et al. Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996;9(2):365–73.

    Article  PubMed  CAS  Google Scholar 

  2. McLellan RA, Drobitch RK, Monshouwer M, et al. Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. Drug Metab Dispos. 1996;24(10):1134–8.

    PubMed  CAS  Google Scholar 

  3. Herrlin K, Segerdahl M, Gustafsson LL, et al. Methadone, ciprofloxacin, and adverse drug reactions. Lancet. 2000;356(9247):2069–70.

    Article  PubMed  CAS  Google Scholar 

  4. Nair MK, Patel K, Starer PJ. Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient. Addiction. 2008;103(12):2062–4.

    Article  PubMed  Google Scholar 

  5. Samoy L, Shalansky KF. Interaction between Methadone and Ciprofloxacin. Can J Hosp Pharm. 2010;63(5):382–4.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, University of Illinois Medical Center, Chicago, IL, USA

    Rani Chovatiya MD

  2. Department of Anesthesiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Mehmet S. Ozcan MD, FCCP

  3. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

Authors
  1. Rani Chovatiya MD
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  2. Mehmet S. Ozcan MD, FCCP
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  3. Randal O. Dull MD, PhD
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Corresponding author

Correspondence to Rani Chovatiya MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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© 2015 Springer Science+Business Media New York

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Chovatiya, R., Ozcan, M.S., Dull, R.O. (2015). Dad’s Not Having Much Pain. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_51

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_51

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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