Abstract
This chapter discusses the genetics, metabolic actions, substrates, and inhibitors of cytochrome P450 2D6.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zhou SF. Polymorphism of human cytochrome P4502D6 and its clinical significance: part 1. Clin Pharmacokinet. 2009;48(11):689–723.
Kosarac B, Fox AA, Collard CD. Effect of genetic factors on opioid action. Curr Opin Anaesthesiol. 2009;22(4):476–82.
Sachse C, Brockmöller J, Hildebrand M, et al. Correctness of prediction of the CYP2D6 phenotype confirmed by genotyping 47 intermediate and poor metabolizers of debrisoquine. Pharmacogenetics. 1998;8(2):181–5.
Shen H, He MM, Liu H, et al. Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10 and CYP2D6.17. Drug Metab Dispos. 2007;35(8):1292–300.
Stamer UM, Stüber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol. 2007;20(5):478–84.
Sohn DR, Shin SG, Park CW, et al. Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations. Br J Clin Pharmacol. 1991;32(4):504–7.
Smith HS. Opioid metabolism. Mayo Clin Proc. 2009;84(7):613–24.
Droll K, Bruce-Mensah K, Otton SV, et al. Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians. Pharmacogenetics. 1998;8(4):325–33.
Williams DG, Patel A, Howard RF. Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. Br J Anaesth. 2002;89(6):839–45.
Voronov P, Przybylo HJ, Jagannathan N. Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer. Paediatr Anaesth. 2007;17(7):684–7.
Madan A, Graham R, Carroll K, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003;31:421–31.
Candiotti KA, Birnbach DJ, Lubarsky DA, et al. The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology. 2005;102(3):543–9.
Janicki PK. Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005;11(10):RA322–8.
Wink J, Veering BT, Kruit M, et al. The effect of a long term epidural infusion of ropivacaine on CYP2D6 activity. Anesth Analg. 2008;106(1):143–6.
Lantz MS, Buchalter EN, Giambanco V. Serotonin syndrome following the administration of tramadol with paroxetine. Int J Geriatr Psychiatry. 1998;13(5):343–5.
Bartelink IH, Rademaker CM, Schobben AF, et al. Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet. 2006;45(11):1077–97.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sanders, J.C., Koll, R., Dull, R.O. (2015). CYP2D6: Where It All Began. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_5
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7495-1_5
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7494-4
Online ISBN: 978-1-4614-7495-1
eBook Packages: MedicineMedicine (R0)