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Determined and Desperate to Diet

Fatal Forty DDI: orlistat, warfarin

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A Case Approach to Perioperative Drug-Drug Interactions

Abstract

This case discusses the drug interactions between orlistat, vitamin K, and warfarin that lead to changes in coagulability.

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References

  1. Masiello P, Mastrogiovanni G, Santoro G, et al. Early massive thrombosis of a mechanical mitral valve. Tex Heart Inst J. 1998;25:303–5.

    PubMed  CAS  PubMed Central  Google Scholar 

  2. Carriere F, Fenou C, Ransac S, et al. Inhibition of gastrointestinal lipolysis by orlistat during digestion of test meals in healthy volunteers. Am J Physiol Gastrointest Liver Physiol. 2001;28:G16–28.

    Google Scholar 

  3. Zhi J, Melia AT, Guerciolini R, et al. Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther. 1994;56:82–5.

    Article  PubMed  CAS  Google Scholar 

  4. Zhi J, Melia AT, Funk C, et al. Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers. J Clin Pharmacol. 1996;36:1006–11.

    Article  PubMed  CAS  Google Scholar 

  5. Filippatos TD, Derdemezis CS, Gazi IF, et al. Orlistat-associated adverse effects and drug interactions. Drug Saf. 2008;31:53–65.

    Article  PubMed  CAS  Google Scholar 

  6. MacWalter RS, Fraser HW, Armstrong KM. Orlistat enhances warfarin effect. Ann Pharmacother. 2003;37(4):510–2.

    Article  PubMed  Google Scholar 

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Correspondence to Lisa Chan MD .

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Chan, L., Lalwani, K. (2015). Determined and Desperate to Diet. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_204

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_204

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

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