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Let’s Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug–Drug Interactions

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A Case Approach to Perioperative Drug-Drug Interactions

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Notes

  1. 1.

    The editors wish to acknowledge that use of the term “The Fatal Forty” in no way implies that any of the cited drugs is a lethal agent. Every drug on this list can be and has been safely, appropriately, and effectively utilized by providers and provided therapeutic benefit to patients. We also acknowledge that even when any of these drugs is involved in a DDI, the likelihood of an outcome as dire as fatality is small. Rather, the “Fatal Forty” name is employed solely as a motivational stratagem to highlight for our readers and students certain drugs that are especially worthy of consideration due to known involvement in clinically significant drug interactions, either by virtue of their prevalence or severity of the interactions in question. The term “Fatal Forty” is employed in the educational context that failure to learn and consider the potential well-recognized DDIs associated with these drugs would prove fatal to the student’s ultimate innate mastery of this most important arena of patient safety.

  2. 2.

    Animal and in vitro DDI data and studies are both valuable from a scientific viewpoint as well as fascinating, however they are beyond the scope of this clinical handbook. Also, although these studies are often the precursors to understanding and recognizing corresponding or similar DDIs in humans, this is not necessarily always the case.

  3. 3.

    Sandson.marcucci@comcast.net

References

  1. Benet LZ. Pharmacokinetics: basic principles and its use as a tool in drug metabolism. In: Mitchell JR, Horning MG, editors. Drug metabolism and drug toxicity. New York: Raven Press; 1984. p. 199.

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  2. US National Library of Medicine, National Institutes of Health. http://www.ncbi.nlm.nih.gov/sites/entrez. Last accessed 21 Sept 2012.

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Author information

Authors and Affiliations

  1. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD,

  2. Perioperative Medicine, Oregon Health and Science University, Department of Anesthesiology, Portland, OR, USA

    Christopher E. Swide MD

  3. Anesthesia Services Department, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA

    Catherine Marcucci MD

Authors
  1. F. Jacob Seagull PhD,
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  2. Christopher E. Swide MD
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  3. Catherine Marcucci MD
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Corresponding author

Correspondence to F. Jacob Seagull PhD, .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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© 2015 Springer Science+Business Media New York

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Seagull, F.J., Swide, C.E., Marcucci, C. (2015). Let’s Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug–Drug Interactions. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_1

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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