Abstract
In this chapter, we will focus on two malignant skin tumors: Merkel cell carcinoma and dermatofibrosarcoma protuberans (DFSP). The histogenesis, epidemiology, pathology, clinical features, diagnosis, and therapy of both tumors will be illustrated.
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References
Darier J, Ferrand M. Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peau. Ann Dermatol Syphiliga. 1924;5:545–62.
Haycox CL, Odland PB, Olbricht SM, Piepkorn M. Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment. J Am Acad Dermatol. 1997;37:438–44.
Chang CK, Jacobs IA, Salti GI. Outcomes of surgery for dermatofibrosarcoma protuberans. Eur J Surg Oncol. 2004;30(3):341–5.
Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995;164(1):129–34.
Gloster HM. Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996;35:355–74.
Criscione VD, Weinstock MA. Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol. 2007;56(6):968–73. Epub 2006 Dec 1.
Taylor HB, Helwig EB. Dermatofibrosarcoma protuberans: a study of 115 cases. Cancer. 1962;15:717–25.
McKee PH, Fletcher CD. Dermatofibrosarcoma protuberans in infancy and childhood. J Cutan Pathol. 1991;18:241–6.
Bowne WB, Antonescu CR, Leung DH, Katz SC, Hawkins WG, Woodruff JM, et al. Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution. Cancer. 2000;88(12):2711–20.
Abeloff MD. Abeloff’s clinical oncology. 4th ed. Philadelphia: Elsevier; 2008: Ch 74; Dupree WB, Langloss JW, Weiss SW. Pigmented dermatofibrosarcoma protuberans (Bednar tumor): a pathologic, ultrastructural and immunohistochemical study. Am J Surg Pathol. 1985;9:630–9.
Klijanienko J, Caillaud JM, Lagacé R. Fine-needle aspiration of primary and recurrent dermatofibrosarcoma protuberans. Diagn Cytopathol. 2004;30(4):261–5; Haycox CL, Odland PB, Olbricht SM, Piepkorn M. Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment. J Am Acad Dermatol. 1997;37(3 Pt 1):438–44.
Abenoza P, Lillemoe T. CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Am J Dermatopathol. 1993;15(5):429–34.
Pedeutour F, Simon MP, Minoletti F, et al. Ring 22 chromosomes in dermatofibrosarcoma protuberans are low level amplifiers of chromosome 17 and 22l sequences. Cancer Res. 1995;55:2400–3.
Bridge JA, Neff JR, Sanberg AA. Cytogenetic analysis of dermatofibrosarcoma protuberans. Cancer Genet Cytogenet. 1990;49:199–202.
No authors listed. Soft tissue sarcoma. In: Greene PL, Page DL, Fleming ID, editors. AJCC cancer staging manual. 6th ed. New York: Verlag; 2002. pp. 193–200.
Arnaud EJ, Perrault M, Revol M, Servant JM, Banzet P. Surgical treatment of dermatofibrosarcoma protuberans. Plast Reconstr Surg. 1997;100(4):884–95.
Paradisi A, Abeni D, Rusciani A, Cigna E, Wolter M, Scuderi N, et al. Dermatofibrosarcoma protuberans: wide local excision vs. Mohs micrographic surgery. Cancer Treat Rev. 2008;34(8):728–36.
Briggaman RA, Wheeler CEJ. The epidermal-dermal junction. J Invest Dermatol. 1975;65:71–84.
Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972;105:107–10.
Tang CK, Toker C. Trabecular carcinoma of the skin: an ultrastructural study. Cancer. 1978;42:2311–21.
Johannessen JV, Gould VE. Neuroendocrine skin carcinoma associated with calcitonin production: a Merkel cell carcinoma? Hum Pathol. 1980;11:586–8.
Hodgson NC. Merkel cell carcinoma: changing incidence trends. J Surg Oncol. 2005;89:1–4.
Boyle F, Pendlebury S, Bell D. Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma. Int J Radiat Oncol Biol Phys. 1995;31:315–23.
Tai PT, Yu E, Winquist E, Hammond A, Stitt L, Tonita J, et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J Clin Oncol. 2000;18:2493–9.
Koljonen V, Bohling T, Granhroth G, Tukiainen E. Merkel cell carcinoma: a clinicopathiological study of 34 patients. Eur J Surg Oncol. 2003;29:607–10.
Connelly TJ, Cribier B, Brown TJ, Yanguas I. Complete spontaneous regression of Merkel cell carcinoma: a review of the 10 reported cases. Dermatol Surg. 2000;26:853–6.
Haag ML, Glass LF, Fenske NA. Merkel cell carcinoma. Diagnosis and treatment. Dermatol Surg. 1995;21:669–83.
Miettinen M. Keratin 20: immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas. Mod Pathol. 1995;8:384–8.
Leong AS, Phillips GE, Pieterse AS, Milios J. Criteria for the diagnosis of primary endocrine carcinoma of the skin (Merkel cell carcinoma). A histological, immunohistochemical and ultrastructural study of 13 cases. Pathology. 1986;18:393–9.
Van Gele M, Leonard JH, Van Roy N, Van Limbergen H, Van Belle S, Cacquyt V, et al. Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer. 2002;101:137–45.
Larramendy ML, Koljonen V, Bohling T, Tukiainen E, Knuutila S. Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas. Mod Pathol. 2004;17:561–7.
Linjawi A, Jamison WB, Meterissian S. Merkel cell carcinoma: important aspects of diagnosis and management. Am Surg. 2001;67:943–7.
Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma. Prognosis and management. Arch Surg. 1991;126:1514–9.
Brisset AE, Olsen KD, Kasperbauer JL, Lewis JE, Goellner JR, Spotts BE, et al. Strome se: Merkel cell carcinoma of the head and neck: a retrospective case series. Head Neck. 2002;24:982–8.
Kolsonen V. Merkel cell carcinoma. World J Surg Oncol 2006;4:7
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Glossary
- CD34
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Glycoproteins found on immature hematopoietic cells and endothelial cells
- Cytokeratin
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Any of a class of fibrous proteins that are intermediate filaments present usually in pairs chiefly in epithelial cells and that are sometimes used as markers to identify malignancies of epithelial origin
- Nerve growth factor receptor
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Any of a family of plasma membrane integral proteins that bind nerve growth factors
- Neuroendocrine tumor
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A tumor that forms from cells that release hormones in response to a signal from the nervous system
- Soft tissue sarcoma
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A malignant tumor that begins in the muscle, fat, fibrous tissue, blood vessels, or other “soft” supporting tissues of the body
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Baldi, F., Fortuño-Mar, A., Bianchi, A., D’Avino, A., Baldi, A. (2014). Pathology of Other Skin Cancer. In: Baldi, A., Pasquali, P., Spugnini, E. (eds) Skin Cancer. Current Clinical Pathology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7357-2_8
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DOI: https://doi.org/10.1007/978-1-4614-7357-2_8
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