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Jugular Interventions for Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency

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Endovascular Interventions

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease resulting in demyelination of the central nervous system. First described pathologically by Robert Carswell in 1838, this disorder typically arises in young adults with approximately 12,000 new diagnoses each year in the United States alone. While the precise cause of this disease has yet to be elucidated, a combination of genetic and environmental factors is felt to be responsible for the autoimmune-mediated nature of this condition.

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References

  1. Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502–17.

    Article  PubMed  CAS  Google Scholar 

  2. Alonso A, Hernán M. Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology. 2008;72:129–35.

    Article  Google Scholar 

  3. Ramagopalan S, Dobson R, Meier UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes and potential causal pathways. Lancet Neurol. 2010;9:727–39.

    Article  PubMed  Google Scholar 

  4. Zamboni P. The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med. 2006;99:589–93.

    Article  PubMed  Google Scholar 

  5. Zamboni P et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009;80:392–9.

    Article  PubMed  CAS  Google Scholar 

  6. Zamboni P, Menegatti E, Galeotti R, et al. The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci. 2009;282:21–7.

    Article  PubMed  Google Scholar 

  7. Simka M et al. Extracranial Doppler sonographic criteria of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. Int Angiol. 2010;29:109–14.

    PubMed  CAS  Google Scholar 

  8. Zivadinov R et al. Prevalence, sensitivity and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology. 2011;77:138–44.

    Article  PubMed  CAS  Google Scholar 

  9. Al-Omari M et al. Internal jugular vein morphology and hemodynamics with multiple sclerosis. Int Angiol. 2010;29:115–20.

    PubMed  CAS  Google Scholar 

  10. Haacke EM, Feng W, Utriainen D, et al. Patients with multiple sclerosis with structural venous abnormalities on MR imaging exhibit an abnormal flow distribution of the internal jugular veins. J Vasc Interv Radiol. 2012;23:60–8.

    Article  PubMed  Google Scholar 

  11. Doepp F et al. No cerebrocervical venous congestion in patients with multiple sclerosis. Ann Neurol. 2010;68:173–83.

    PubMed  Google Scholar 

  12. Tsivgoulis G, Manatzis M, Bogiatzi C, et al. Extracranial venous hemodynamics in multiple sclerosis: a case–control study. Neurology. 2011;77:1241–5.

    Article  PubMed  CAS  Google Scholar 

  13. Centonze D, Floris R, Stafanini M, et al. Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity. Ann Neurol. 2011;70:51–8.

    Article  PubMed  Google Scholar 

  14. Mayer C. The perfect crime? CCSVI not leaving a trace in MS. J Neurol Neurosurg Psychiatry. 2011;82:436–40.

    Article  PubMed  Google Scholar 

  15. Baracchini C, Perini P, Causin F, et al. Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency. Neurology. 2011;77:844–50.

    Article  PubMed  CAS  Google Scholar 

  16. Marder E, Gupta P, Greenberg BM, et al. No cerebral or cervical venous insufficiency in US veterans with multiple sclerosis. Arch Neurol. 2011;68:1521–5.

    Article  PubMed  Google Scholar 

  17. Hojnacki D, Zamboni P, Lopez-Soriano A, et al. Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls. Int Angiol. 2010;29:127–39.

    PubMed  CAS  Google Scholar 

  18. Zamboni P et al. A prospective open label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vasc Surg. 2009;50:1348–58.

    Article  PubMed  Google Scholar 

  19. Malagoni AM, Galeotti R, Menegatti E, et al. Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study. Int Angiol. 2010;29:176–82.

    PubMed  CAS  Google Scholar 

  20. Dake MD, Dantzker N, Bennett WL, Cooke JP. Endovascular correction of cerebrovenous anomalies in multiple sclerosis: a retrospective review of an uncontrolled case series. Vasc Med. 2012; 17:131–7.

    Article  PubMed  Google Scholar 

  21. Aboulker J, Aubin ML, Leriche H, et al. Intraspinal venous hypertension due to multiple anomalies in the caval system. A major cause of myelopathies. Acta Radiol Suppl. 1976;347:395–401.

    PubMed  CAS  Google Scholar 

  22. Morimoto A et al. Assessment of cervical venous blood flow and the craniocervical venous valve using ultrasound. Leg Med. 2009;11:10–7.

    Article  Google Scholar 

  23. Werner J, Siskin GP, Mandato K, Englander M, Herr A. Review of venous anatomy for venographic interpretation in chronic cerebrospinal venous insufficiency. J Vasc Interv Radiol. 2011;22:1681–90.

    Article  PubMed  Google Scholar 

  24. Patra P et al. Physiologic variations of the internal jugular vein surface, role of the omohyoid muscle, a preliminary echographic study. Surg Radiol Anat. 1988;10:107–12.

    Article  PubMed  CAS  Google Scholar 

  25. Escott EJ, Branstetter BF. It’s not a cervical lymph node, it’s a vein: CT and MR imaging findings in the veins of the head and neck. Radiographics. 2006;26:1501–15.

    Article  PubMed  Google Scholar 

  26. Lim CL, Keshava SN, Lea M. Anatomical variations of the internal jugular veins and their relationship to the carotid arties: a CT evaluation. Australas Radiol. 2006;50:314–8.

    Article  PubMed  CAS  Google Scholar 

  27. Diaconu C, Staugaitis S, McBride J, et al. Anatomical and histological analysis of venous structures associated with chronic cerebrospinal venous insufficiency [abstract 134]. In: 5’th joint triennial congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis, Amsterdam, October 2011.

    Google Scholar 

  28. Petrov I, Grozdinski L, Kaninski G, et al. Safety profile of endovascular treatment for chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Endovasc Ther. 2011;18:314–23.

    Article  PubMed  Google Scholar 

  29. Ludyga T, Kazibudzki M, Simka M, et al. Endovascular treatment for chronic cerebrospinal venous insufficiency: is the procedure safe? Phlebology. 2010;25:286–95.

    Article  PubMed  CAS  Google Scholar 

  30. Mandato KD, Hegener PF, Siskin GP, et al. Safety of endovascular treatment of chronic cerebrospinal venous insufficiency: a report of 240 patients with multiple sclerosis. J Vasc Interv Radiol. 2012;23:55–9.

    Article  PubMed  Google Scholar 

  31. Qiu J. Venous abnormalities and multiple sclerosis: another breakthrough claim? Lancet Neurol. 2010;9:464–5.

    Article  PubMed  Google Scholar 

  32. Burton JM, Alikhani K, Goyal M. Complications in MS patients after CCSVI procedures abroad (Calgary, AB). Can J Neurol Sci. 2011;38:741–6.

    PubMed  Google Scholar 

  33. Aksungar FB, Topkaya AE, Yildiz Z, et al. Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J Clin Neurosci. 2008;15:393–7.

    Article  PubMed  CAS  Google Scholar 

  34. Nappo F, De Rosa N, Marfella R, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA. 1999;281:2113–8.

    Article  PubMed  CAS  Google Scholar 

  35. Kuch B, Bobak M, Fobker M, et al. Associations between homocysteine and coagulation factors – a cross sectional study in two populations of central Europe. Thromb Res. 2001;103:265–73.

    Article  PubMed  CAS  Google Scholar 

  36. Nathanson M, Savitsky JP. Platelet adhesiveness index studies in multiple sclerosis and other neurologic disorders. Bull N Y Acad Med. 1952;28:462–8.

    PubMed  CAS  Google Scholar 

  37. Wright HP, Thompson RHS, Zikha KJ. Platelet adhesiveness in multiple sclerosis. Lancet. 1965;2:1109–10.

    Article  PubMed  CAS  Google Scholar 

  38. Sheremata WA, Jy W, Horstman LL, et al. Evidence of platelet activation in multiple sclerosis. J Neuroinflammation. 2008;5:27.

    Article  PubMed  Google Scholar 

  39. Bidot CJ, Horstman LL, Jy W, et al. Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: a preliminary study. BMC Neurol. 2007;7:36.

    Article  PubMed  Google Scholar 

  40. Donnet A, Metellus P, Levrier O, et al. Endovascular treatment of idiopathic intracranial hypertension: clinical and radiologic outcome of 10 consecutive patients. Neurology. 2008;70:641–7.

    Article  PubMed  CAS  Google Scholar 

  41. Bussiere M, Falero R, Nicolle D, et al. Unilateral transverse sinus stenting of patients with idiopathic intracranial hypertension. AJNR Am J Neuroradiol. 2010;31:645–50.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Albany Medical Center Hospital, 47 New Scotland Avenue, MC-113, Albany, NY, 12203, USA

    Jason P. Vachon MD & Gary P. Siskin MD

Authors
  1. Jason P. Vachon MD
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  2. Gary P. Siskin MD
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Editor information

Editors and Affiliations

  1. Edward Hines, Jr. VA Hospital Loyola University Medical Center, Glen Ellyn, Illinois, USA

    Robert S. Dieter

  2. Northern Illinois Surgery Center, Naperville, Illinois, USA

    Raymond A. Dieter, Jr.

  3. University of Tennessee Medical Center, Knoxville, Tennessee, USA

    Raymond A. Dieter, III

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Vachon, J.P., Siskin, G.P. (2014). Jugular Interventions for Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency. In: Dieter, R., Dieter, Jr., R., Dieter, III, R. (eds) Endovascular Interventions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7312-1_78

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  • DOI: https://doi.org/10.1007/978-1-4614-7312-1_78

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7311-4

  • Online ISBN: 978-1-4614-7312-1

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