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Obesity, Inflammation, and Prostate Cancer

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

Obesity and the associated metabolic syndrome produce a complex set of alterations both systemically and locally in tissues that support cancer development and progression. In prostate cancer (PCa), the weight of evidence suggests that obesity is primarily associated with more aggressive disease and increased risk of biochemical failure following prostatectomy or radiation treatment. Inflammation processes and inflammation-associated signaling pathways are upregulated in the obese state, and both human and mouse studies support an important role for inflammation in obesity-driven PCa progression. Inflammation signaling pathways along with other signaling pathways (e.g., growth factor signaling pathways) altered in the obese state represent promising targets for both lifestyle and pharmacologic interventions to prevent or control PCa progression.

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Acknowledgments

Achinto Saha is supported by a Cancer Prevention Research Institute of Texas postdoctoral fellowship award RP101501 from the State of Texas.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78723, USA

    Jorge Blando, Achinto Saha, Kaoru Kiguchi & John DiGiovanni Ph.D.

  2. Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX, 78723, USA

    John DiGiovanni Ph.D.

  3. Dell Pediatric Research Institute, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA

    John DiGiovanni Ph.D.

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  1. Jorge Blando
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  2. Achinto Saha
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  3. Kaoru Kiguchi
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  4. John DiGiovanni Ph.D.
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Correspondence to John DiGiovanni Ph.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Blando, J., Saha, A., Kiguchi, K., DiGiovanni, J. (2013). Obesity, Inflammation, and Prostate Cancer. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_10

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