Abstract
Wilms’ tumor is a malignant neoplasm derived from nephrogenic blastema and is the most common renal tumor of childhood. It comprises about 85 % of renal tumors and 7 % of all pediatric tumors. The incidence is around 1 in 8,000. Ninety percent are sporadic and 10 % are associated with one of several syndromes, some of which are associated with abnormalities of the WT1 gene. The vast majority of Wilms’ tumors present with an abdominal mass, which is usually detected incidentally by caretakers. Other symptoms and signs may include abdominal pain, hematuria, and hypertension. The classical histological features of a triphasic Wilms’ tumor include epithelial, stromal, and blastemal elements. The blastemal component of Wilms’ tumor has a high nuclear-to-cytoplasmic ratio with closely packed nuclei, nuclear overlapping, and mitoses. The chromatin is often finely dispersed. The cells may appear focally dyscohesive.
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Gilbert-Barness, E., Spicer, D.E., Steffensen, T.S. (2014). Pediatric Tumors. In: Handbook of Pediatric Autopsy Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6711-3_17
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DOI: https://doi.org/10.1007/978-1-4614-6711-3_17
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