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Utility of Electrolyte-Free Water Clearance in the Analysis and Treatment of the Dysnatremias

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Hyponatremia

Abstract

Understanding the pathogenesis and treatment of hyponatremia is a challenge for medical students and experts alike. Although hyponatremia has a wide range of causes, the pathogenesis of hyponatremia is largely characterized by disorders of urinary dilution. In evaluating the renal mechanisms responsible for the pathophysiology of hyponatremia, an analysis of free water clearance (FWC) and electrolyte-free water clearance (EFWC) is often utilized to quantify the renal diluting defect in this disorder. In this article, the utility of free water clearance (FWC) and electrolyte-free water clearance (EFWC) in the diagnostic and therapeutic approach to hyponatremia is discussed.

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Authors and Affiliations

  1. Division of Nephrology, Ronald Reagan UCLA Medical Center, 757 Westwood Blvd, Rm. 7501B, Los Angeles, CA, 90095-7417, USA

    Minhtri Khac Nguyen

  2. Nephrology, UCLA, Los Angeles, CA, USA

    Huma Hasnain

  3. Department of Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA, USA

    Michael J. DiBiase

  4. Division of Nephrology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA

    Carl Schulze

  5. Medicine/Nephrology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA

    Ira Kurtz

Authors
  1. Minhtri Khac Nguyen
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  2. Huma Hasnain
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  3. Michael J. DiBiase
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  4. Carl Schulze
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  5. Ira Kurtz
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Corresponding author

Correspondence to Minhtri Khac Nguyen .

Editor information

Editors and Affiliations

  1. Section of Nephrology and Hypertension, Tulane University Health Sciences Center, Tulane Ave 1430, New Orleans, 70112, Louisiana, USA

    Eric E. Simon

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Nguyen, M.K., Hasnain, H., DiBiase, M.J., Schulze, C., Kurtz, I. (2013). Utility of Electrolyte-Free Water Clearance in the Analysis and Treatment of the Dysnatremias. In: Simon, E. (eds) Hyponatremia. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6645-1_3

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  • DOI: https://doi.org/10.1007/978-1-4614-6645-1_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6644-4

  • Online ISBN: 978-1-4614-6645-1

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