Abstract
Preparation, dispensing, and patient education regarding appropriate use of pharmaceuticals are primarily the responsibility of the pharmacist. Traditionally, parenteral products have been available in ready-to-use containers or required dilution with water or saline prior to use with no other special handling requirements. Hospital pharmacists, in particular, have prepared and dispensed parenteral products for individual patients for many years. While many pharmacists are skilled in handling parenteral products, biotechnology products present additional challenges since they are proteins subject to denaturation and thus require special handling techniques. These challenges will be explained in greater detail in this chapter. Practice issues with biotechnology products may be handled in slightly different ways depending on laws and pharmacy practice standards in each country. This chapter is written primarily from the view of practice in the United States since that is the primary experience of the authors.
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References
Abbott Laboratories (2011) Humira® full prescribing information. North Chicago
American Society of Health-System Pharmacists (2000) ASHP guidelines on quality assurance for pharmacy-prepared sterile products. Am J Health Syst Pharm 57(12):1150–1169
Amgen Inc. (2007) Neupogen® full prescribing information. Thousand Oaks
Amgen Inc. (2011) Epogen® full prescribing information. Thousand Oaks
Banga AK, Reddy IK (1994) Biotechnology drugs: pharmaceutical issues. Pharm Times 60:68–76
Bayer HealthCare (2010) Betaseron® full prescribing information. Montville
Caremark (2006) Trends Rx Report, Focus on specialty pharmacy. Northbrook
Catania P (2010) King guide to parenteral admixture. King Guide Publications, Inc. St Louis
Department of Health and Human Services (2010) CMS manual system, Pub 100–02 Medicare Benefit Policy, Transmittal 123
Fein AJ (2010) 2010–11 Economic report on retail and specialty pharmacies. Pembroke Consulting, Philadelphia
Genentech, Inc. (1994) Pulmozyme® full prescribing information. South San Francisco
Genentech, Inc. (2011) Activase® full prescribing information. South San Francisco
Genzyme Corporation (2009) Leukine® full prescribing information. Cambridge
Koeller J, Fields S (1991) The pharmacist’s role with biotechnology products. The Upjohn Company, Kalamazoo
McDermott DF, Regan MM, Clark JI et al (2005) Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23(1):133–141
McEvoy GK (2011) American hospital formulary service drug information. American Society of Health-System Pharmacists, Bethesda
Prometheus Therapeutics (2011) Proleukin® full prescribing information. Emeryville
Roche Laboratories (2005) Summary of product characteristics. Accessed at: http://www.rocheuk.com/ProductDB/Documents/rx/spc/Roferon-A_Cartridge_SPC.pdf. Accessed 31 Oct 2006
Schering Laboratories (2004) Intron® full prescribing information. Kenilworth, Schering Laboratories
Suchanek D (2005) The rise and role of specialty pharmacy. Biotechnol Healthc 2:31–35
Further Reading
See Tables 9.1, 9.5, and 9.6 for suggested readings
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Piascik, P., Adams, V. (2013). Dispensing Biotechnology Products: Handling, Professional Education, and Product Information. In: Crommelin, D., Sindelar, R., Meibohm, B. (eds) Pharmaceutical Biotechnology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6486-0_9
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DOI: https://doi.org/10.1007/978-1-4614-6486-0_9
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