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Kisspeptin and Clinical Disorders

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Kisspeptin Signaling in Reproductive Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 784))

Abstract

The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult. Pathways governing GnRH ontogeny and physiology have been discovered by studying humans with disorders of GnRH secretion. In this chapter, the human genetics of the kisspeptin signaling pathway in patients with diverse reproductive phenotypes will be explored. The discovery of defects in the kisspeptin system in several reproductive disorders has shed light on the mechanisms involved in regulating GnRH secretion, revealing the critical role played by the kisspeptin signaling pathway in pubertal initiation and reproductive function.

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Acknowledgments

Dr. Seminara and some of the data referenced in this article were supported by the Eunice Kennedy Shriver NICHD/NIH through cooperative agreement [U54 HD028138] as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research, as well as R01 HD043341 and K24 HD067388.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Endocrinology and Metabolism, Hospital das Clinicas, Sao Paulo University, Sao Paulo, Brazil

    Letícia Gontijo Silveira & Ana Claudia Latronico

  2. Department of Internal Medicine, Reproductive Endocrine Unit, Bartlett Hall Extension 504, Endocrine Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Stephanie Beth Seminara M.D.

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  1. Letícia Gontijo Silveira
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  2. Ana Claudia Latronico
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  3. Stephanie Beth Seminara M.D.
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Correspondence to Stephanie Beth Seminara M.D. .

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  1. , Department of Reproductive Medicine, University of California, San Diego, La Jolla, 92093, California, USA

    Alexander S. Kauffman

  2. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Hackett Drive, Nedlands, 6009, West Australia, Australia

    Jeremy T. Smith

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Silveira, L.G., Latronico, A.C., Seminara, S.B. (2013). Kisspeptin and Clinical Disorders. In: Kauffman, A., Smith, J. (eds) Kisspeptin Signaling in Reproductive Biology. Advances in Experimental Medicine and Biology, vol 784. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6199-9_9

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