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Chromatin Looping and Long Distance Regulation by Androgen Receptor

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Androgen-Responsive Genes in Prostate Cancer

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Abstract

The importance of the androgen signaling axis to the development and progression of prostate cancer (PCa) is central to our understanding of the disease and the therapeutic strategies currently utilized against it. The androgen receptor (AR) is known to transform the hormone stimulatory signal into an oncogenic gene transcription program required for PCa initiation and progression. Bound by AR primarily at their distal enhancer elements, AR target gene transcription relies on a mechanism known as chromatin looping. Increasingly abundant evidence suggests that changing patterns in AR-mediated chromatin loop formation underlie alterations in gene expression profiles among PCa cases and throughout PCa progression. Defining the role of additional loop-facilitating activities and the impact of genome organization on the patterns of AR-mediated chromatin interactions remains an obstacle to full understanding of transcription regulation by AR.

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Acknowledgment

We thank Dr. Zhong Chen for his critical reading of the manuscript.

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  1. Ohio State Biochemistry Graduate Program, The Ohio State University College of Medicine, Columbus, OH, USA

    Benjamin Sunkel

  2. Department of Molecular and Cellular Biochemistry and Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA

    Qianben Wang

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Correspondence to Qianben Wang .

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  1. , Shadyside Medical Center, University of Pittsburgh, Centre Ave 5200, Pittsburgh, 15232, Pennsylvania, USA

    Zhou Wang

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Sunkel, B., Wang, Q. (2013). Chromatin Looping and Long Distance Regulation by Androgen Receptor. In: Wang, Z. (eds) Androgen-Responsive Genes in Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6182-1_4

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