Skip to main content

Upper Gastrointestinal Bleeding

  • Chapter
  • First Online:
Common Problems in Acute Care Surgery

Abstract

Upper gastrointestinal bleeding (UGIB) is a common problem and frequently generates a consult for the acute care surgeon. Although very few patients with this complaint ultimately have any surgical intervention, surgeons have historically been intimately involved in the management of UGIB patients. With the discovery of Helicobacter pylori, effective H. pylori treatment and eradication regimens have greatly decreased the incidence of peptic ulcer disease as well as shifted the algorithm away from surgical treatment. Moreover, there appears to be a decreasing incidence and mortality of peptic ulcer disease as well as a decrease in acute UGIB related to peptic ulcer disease [1]. Recent data suggests that surgical intervention for any symptom or complication of peptic ulcer disease have declined more than 80 % [2]. Moreover, the fields of diagnostic and therapeutic endoscopy as well as interventional radiology have expanded in directions that have had a huge impact on the treatment options available for the patient with an UGIB. The role of the surgeon will often be to assist their colleagues in guiding the patient into an informed and evidence based plan of action.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lanas A. Editorial: upper GI bleeding-associated mortality: challenges to improving a resistant outcome. Am J Gastroenterol. 2010;105(1):90–2.

    Article  PubMed  Google Scholar 

  2. van Leerdam ME. Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol. 2008;22(2):209–24.

    Article  PubMed  Google Scholar 

  3. Statistics for U.S. community hospital stays, prinicpal diagnosis based on CCS, 2009. 2011. Agency for Healthcare Research and Quality. 7-13-2001. Ref Type: Online Source

    Google Scholar 

  4. Schenker MP, Majdalany BS, Funaki BS, et al. ACR Appropriateness Criteria(R) on upper gastrointestinal bleeding. J Am Coll Radiol. 2010;7(11):845–53.

    Article  PubMed  Google Scholar 

  5. van Leerdam ME, Vreeburg EM, Rauws EA, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol. 2003;98(7):1494–9.

    Article  PubMed  Google Scholar 

  6. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2006;  (2):CD003840.

    Google Scholar 

  7. Feldman M, Shewmake K, Cryer B. Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans. Am J Physiol Gastrointest Liver Physiol. 2000;279(5):G1113–20.

    PubMed  CAS  Google Scholar 

  8. Papatheodoridis GV, Papadelli D, Cholongitas E, Vassilopoulos D, Mentis A, Hadziyannis SJ. Effect of helicobacter pylori infection on the risk of upper gastrointestinal bleeding in users of nonsteroidal anti-inflammatory drugs. Am J Med. 2004;116(9):601–5.

    Article  PubMed  CAS  Google Scholar 

  9. Johnson HD. Gastric ulcer: classification, blood group characteristics, secretion patterns and pathogenesis. Ann Surg. 1965;162(6):996–1004.

    Article  PubMed  CAS  Google Scholar 

  10. Vesely KT, Kubickova Z, Dvorakova M. Clinical data and characteristics differentiating types of peptic ulcer. Gut. 1968;9(1):57–68.

    Article  PubMed  CAS  Google Scholar 

  11. Sachs G, Shin JM, Munson K, et al. Review article: the control of gastric acid and Helicobacter pylori eradication. Aliment Pharmacol Ther. 2000;14(11):1383–401.

    Article  PubMed  CAS  Google Scholar 

  12. Collen MJ, Sheridan MJ. Gastric ulcers differ from duodenal ulcers. Evaluation of basal acid output. Dig Dis Sci. 1993;38(12):2281–6.

    Article  PubMed  CAS  Google Scholar 

  13. Del Olmo JA, Pena A, Serra MA, Wassel AH, Benages A, Rodrigo JM. Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis. J Hepatol. 2000;32(1):19–24.

    Article  PubMed  Google Scholar 

  14. Curvelo LA, Brabosa W, Rhor R, et al. Underlying mechanism of portal hypertensive gastropathy in cirrhosis: a hemodynamic and morphological approach. J Gastroenterol Hepatol. 2009;24(9):1541–6.

    Article  PubMed  Google Scholar 

  15. Harbison SP, Dempsey DT. Mallory-Weiss syndrome. In: Cameron JL, editor. Current surgical therapy. 9th ed. Philadelphia, PA: Mosby Elselvier; 2008.

    Google Scholar 

  16. Baxter M, Aly EH. Dieulafoy’s lesion: current trends in diagnosis and management. Ann R Coll Surg Engl. 2010;92(7):548–54.

    Article  PubMed  CAS  Google Scholar 

  17. Lara LF, Sreenarasimhaiah J, Tang SJ, Afonso BB, Rockey DC. Dieulafoy lesions of the GI tract: localization and therapeutic outcomes. Dig Dis Sci. 2010;55(12):3436–41.

    Article  PubMed  Google Scholar 

  18. Hollander JE, Quick G. Aortoesophageal fistula: a comprehensive review of the literature. Am J Med. 1991;91(3):279–87.

    Article  PubMed  CAS  Google Scholar 

  19. Pipinos II, Carr JA, Haithcock BE, Anagnostopoulos PV, Dossa CD, Reddy DJ. Secondary aortoenteric fistula. Ann Vasc Surg. 2000;14(6):688–96.

    Article  PubMed  CAS  Google Scholar 

  20. Mirsadraee S, Tirukonda P, Nicholson A, Everett SM, McPherson SJ. Embolization for non-variceal upper gastrointestinal tract haemorrhage: a systematic review. Clin Radiol. 2011;66(6):500–9.

    Article  PubMed  CAS  Google Scholar 

  21. Hungness ES. Gastrointestinal bleeding. In: Ashley S, Wilmore D, editors. ACS surgery: principles and practice. BC Decker: Hamilton, ON; 2011.

    Google Scholar 

  22. Rand ML, Leung R, Packham MA. Platelet function assays. Transfus Apher Sci. 2003;28(3):307–17.

    Article  PubMed  Google Scholar 

  23. Palamidessi N, Sinert R, Falzon L, Zehtabchi S. Nasogastric aspiration and lavage in emergency department patients with hematochezia or melena without hematemesis. Acad Emerg Med. 2010;17(2):126–32.

    Article  PubMed  Google Scholar 

  24. Lau JY, Sung JJ, Lam YH, et al. Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. N Engl J Med. 1999;340(10):751–6.

    Article  PubMed  CAS  Google Scholar 

  25. Chua AE, Ridley LJ. Diagnostic accuracy of CT angiography in acute gastrointestinal bleeding. J Med Imaging Radiat Oncol. 2008;52(4):333–8.

    Article  PubMed  CAS  Google Scholar 

  26. Kuhle WG, Sheiman RG. Detection of active colonic hemorrhage with use of helical CT: findings in a swine model. Radiology. 2003;228(3):743–52.

    Article  PubMed  Google Scholar 

  27. Bentley DE, Richardson JD. The role of tagged red blood cell imaging in the localization of gastrointestinal bleeding. Arch Surg. 1991;126(7):821–4.

    Article  PubMed  CAS  Google Scholar 

  28. Winzelberg GG, McKusick KA, Froelich JW, Callahan RJ, Strauss HW. Detection of gastrointestinal bleeding with 99mTc-labeled red blood cells. Semin Nucl Med. 1982;12(2):139–46.

    Article  PubMed  CAS  Google Scholar 

  29. Loffroy R, Guiu B. Role of transcatheter arterial embolization for massive bleeding from gastroduodenal ulcers. World J Gastroenterol. 2009;15(47):5889–97.

    Article  PubMed  Google Scholar 

  30. Defreyne L, De Schrijver I, Decruyenaere J, et al. Therapeutic decision-making in endoscopically unmanageable nonvariceal upper gastrointestinal hemorrhage. Cardiovasc Intervent Radiol. 2008;31(5):897–905.

    Article  PubMed  Google Scholar 

  31. Loffroy R, Guiu B, Cercueil JP, et al. Refractory bleeding from gastroduodenal ulcers: arterial embolization in high-operative-risk patients. J Clin Gastroenterol. 2008;42(4):361–7.

    Article  PubMed  Google Scholar 

  32. Loffroy R, Guiu B, Mezzetta L, et al. Short- and long-term results of transcatheter embolization for massive arterial hemorrhage from gastroduodenal ulcers not controlled by endoscopic hemostasis. Can J Gastroenterol. 2009;23(2):115–20.

    PubMed  Google Scholar 

  33. Ripoll C, Banares R, Beceiro I, et al. Comparison of transcatheter arterial embolization and surgery for treatment of bleeding peptic ulcer after endoscopic treatment failure. J Vasc Interv Radiol. 2004;15(5):447–50.

    Article  PubMed  Google Scholar 

  34. Eriksson LG, Ljungdahl M, Sundbom M, Nyman R. Transcatheter arterial embolization versus surgery in the treatment of upper gastrointestinal bleeding after therapeutic endoscopy failure. J Vasc Interv Radiol. 2008;19(10):1413–8.

    Article  PubMed  Google Scholar 

  35. Defreyne L, Vanlangenhove P, De VM, et al. Embolization as a first approach with endoscopically unmanageable acute nonvariceal gastrointestinal hemorrhage. Radiology. 2001;218(3):739–48.

    PubMed  CAS  Google Scholar 

  36. Larssen L, Moger T, Bjornbeth BA, Lygren I, Klow NE. Transcatheter arterial embolization in the management of bleeding duodenal ulcers: a 5.5-year retrospective study of treatment and outcome. Scand J Gastroenterol. 2008;43(2):217–22.

    Article  PubMed  Google Scholar 

  37. Schirmer BD. Bleeding duodenal ulcer. In: Fischer JE, Bland KI, editors. Mastery of surgery. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007.

    Google Scholar 

  38. Winkleman BJ, Usatii A, Ellison EC. Duodenal ulcer. In: Cameron JL, editor. Current surgical therapy. 9th ed. Philadelphia, PA: Mosby Elselvier; 2008.

    Google Scholar 

  39. Donahue PE. Parietal cell vagotomy versus vagotomy-antrectomy: ulcer surgery in the modern era. World J Surg. 2000;24(3):264–9.

    Article  PubMed  CAS  Google Scholar 

  40. Guinier D, Destrumelle N, Denue PO, Mathieu P, Heyd B, Mantion GA. Technique of antroduodenectomy without ulcer excision as a safe alternative treatment for bleeding chronic duodenal ulcers. World J Surg. 2009;33(5):1010–4.

    Article  PubMed  Google Scholar 

  41. Siewert JR, Bumm R. Distal gastrectomy with Bilroth I, Bilroth II, or Roux-Y reconstruction. In: Fischer JE, Bland KI, editors. Mastery of surgery. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007.

    Google Scholar 

  42. Fisher WE, Brunicardi FC. Benign gastric ulcer. In: Cameron JL, editor. Current surgical therapy. 9th ed. Philadelphia, PA: Mosby Elsevier; 2008.

    Google Scholar 

  43. Poxon VA, Keighley MR, Dykes PW, Heppinstall K, Jaderberg M. Comparison of minimal and conventional surgery in patients with bleeding peptic ulcer: a multicentre trial. Br J Surg. 1991;78(11):1344–5.

    Article  PubMed  CAS  Google Scholar 

  44. Millat B, Hay JM, Valleur P, Fingerhut A, Fagniez PL. Emergency surgical treatment for bleeding duodenal ulcer: oversewing plus vagotomy versus gastric resection, a controlled randomized trial. French Associations for Surgical Research. World J Surg. 1993;17(5):568–73.

    Article  PubMed  CAS  Google Scholar 

  45. Arroyo MT, Forne M, de Argila CM, et al. The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter. 2004;9(3):249–54.

    Article  PubMed  Google Scholar 

  46. Miehlke S, Bayerdorffer E, Lehn N, et al. Two-year follow-up of duodenal ulcer patients treated with omeprazole and amoxicillin. Digestion. 1995;56(3):187–93.

    Article  PubMed  CAS  Google Scholar 

  47. Rokkas T, Karameris A, Mavrogeorgis A, Rallis E, Giannikos N. Eradication of Helicobacter pylori reduces the possibility of rebleeding in peptic ulcer disease. Gastrointest Endosc. 1995;41(1):1–4.

    Article  PubMed  CAS  Google Scholar 

  48. Leung WK, Sung JJ, Siu KL, Chan FK, Ling TK, Cheng AF. False-negative biopsy urease test in bleeding ulcers caused by the buffering effects of blood. Am J Gastroenterol. 1998;93(10):1914–8.

    Article  PubMed  CAS  Google Scholar 

  49. Grino P, Pascual S, Such J, et al. Comparison of diagnostic methods for Helicobacter pylori infection in patients with upper gastrointestinal bleeding. Scand J Gastroenterol. 2001;36(12):1254–8.

    Article  PubMed  CAS  Google Scholar 

  50. Gisbert JP, Calvet X. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther. 2009;30(8):791–815.

    Article  PubMed  CAS  Google Scholar 

  51. Zheng M, Chen Y, Bai J, et al. Transjugular intrahepatic portosystemic shunt versus endoscopic therapy in the secondary prophylaxis of variceal rebleeding in cirrhotic patients: meta-analysis update. J Clin Gastroenterol. 2008;42(5):507–16.

    Article  PubMed  Google Scholar 

  52. Orloff MJ, Isenberg JI, Wheeler HO, et al. Portal-systemic encephalopathy in a randomized controlled trial of endoscopic sclerotherapy versus emergency portacaval shunt treatment of acutely bleeding esophageal varices in cirrhosis. Ann Surg. 2009;250(4):598–610.

    PubMed  Google Scholar 

  53. Mathur SK, Shah SR, Nagral SS, Soonawala ZF. Transabdominal extensive esophagogastric devascularization with gastroesophageal stapling for management of noncirrhotic portal hypertension: long-term results. World J Surg. 1999;23(11):1168–74.

    Article  PubMed  CAS  Google Scholar 

  54. Lee JH, Han HS, Kim HA, Koo MY. Long-term results of fundectomy and periesophagogastric devascularization in patients with gastric fundal variceal bleeding. World J Surg. 2009;33(10):2144–9.

    Article  PubMed  Google Scholar 

  55. Chiu PW, Ng EK. Predicting poor outcome from acute upper gastrointestinal hemorrhage. Gastroenterol Clin North Am. 2009;38(2):215–30.

    Article  PubMed  Google Scholar 

  56. Lanas A, Aabakken L, Fonseca J, et al. Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe. Aliment Pharmacol Ther. 2011;33(11):1225–33.

    Article  PubMed  CAS  Google Scholar 

  57. Villanueva C, Balanzo J, Espinos JC, et al. Prediction of therapeutic failure in patients with bleeding peptic ulcer treated with endoscopic injection. Dig Dis Sci. 1993;38(11):2062–70.

    Article  PubMed  CAS  Google Scholar 

  58. Brullet E, Calvet X, Campo R, Rue M, Catot L, Donoso L. Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer. Gastrointest Endosc. 1996;43(2 Pt 1):111–6.

    Article  PubMed  CAS  Google Scholar 

  59. Brullet E, Campo R, Calvet X, Coroleu D, Rivero E, Simo DJ. Factors related to the failure of endoscopic injection therapy for bleeding gastric ulcer. Gut. 1996;39(2):155–8.

    Article  PubMed  CAS  Google Scholar 

  60. Guglielmi A, Ruzzenente A, Sandri M, et al. Risk assessment and prediction of rebleeding in bleeding gastroduodenal ulcer. Endoscopy. 2002;34(10):778–86.

    Article  PubMed  CAS  Google Scholar 

  61. Wong SK, Yu LM, Lau JY, et al. Prediction of therapeutic failure after adrenaline injection plus heater probe treatment in patients with bleeding peptic ulcer. Gut. 2002;50(3):322–5.

    Article  PubMed  CAS  Google Scholar 

  62. Kim BJ, Park MK, Kim SJ, et al. Comparison of scoring systems for the prediction of outcomes in patients with nonvariceal upper gastrointestinal bleeding: a prospective study. Dig Dis Sci. 2009;54(11):2523–9.

    Article  PubMed  Google Scholar 

  63. Sung JJ, Tsoi KK, Ma TK, Yung MY, Lau JY, Chiu PW. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol. 2010;105(1):84–9.

    Article  PubMed  Google Scholar 

  64. Clarke MG, Bunting D, Smart NJ, Lowes J, Mitchell SJ. The surgical management of acute upper gastrointestinal bleeding: a 12-year experience. Int J Surg. 2010;8(5):377–80.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter Rhee M.D., M.P.H., F.A.C.S., F.C.C.M., D.M.C.C. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gries, L., Rhee, P. (2013). Upper Gastrointestinal Bleeding. In: Moore, L., Turner, K., Todd, S. (eds) Common Problems in Acute Care Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6123-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6123-4_19

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6122-7

  • Online ISBN: 978-1-4614-6123-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics