Skip to main content
SpringerLink
Log in

High Risk Breast Lesions and Pathologic Evaluation

  • Chapter
  • First Online:
Management of the Patient at High Risk for Breast Cancer

Abstract

There are several pathologic lesions in the female breast that are so-called “high risk” because of epidemiologic data suggesting that a diagnosis of one of these lesions on a biopsy increases a woman’s risk of developing a subsequent carcinoma. Among the most common of these lesions are lobular neoplasia (atypical lobular hyperplasia and lobular carcinoma in situ), columnar cell lesions (including flat epithelial atypia), atypical ductal hyperplasia, papillary lesions, and radial scar/complex sclerosing lesions. In this chapter, the specific histopathologic diagnostic criteria for each of these lesions will be discussed and associated images of each will be displayed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Foote FW, Stewart FW. Lobular carcinoma in situ: a rare form of mammary cancer. Am J Pathol. 1941;17(4):491–496.3.

    PubMed  CAS  Google Scholar 

  2. Simpson PT, et al. The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ. Breast Cancer Res. 2003;5(5):258–62.

    Article  PubMed  Google Scholar 

  3. Haagensen CD, et al. Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. Cancer. 1978;42(2):737–69.

    Article  PubMed  CAS  Google Scholar 

  4. Jacobs TW, et al. Carcinomas in situ of the breast with indeterminate features: role of E-cadherin staining in categorization. Am J Surg Pathol. 2001;25(2):229–36.

    Article  PubMed  CAS  Google Scholar 

  5. Maluf HM, Swanson PE, Koerner FC. Solid low-grade in situ carcinoma of the breast: role of associated lesions and E-cadherin in differential diagnosis. Am J Surg Pathol. 2001;25(2):237–44.

    Article  PubMed  CAS  Google Scholar 

  6. Page DL, et al. Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer. 1985;55(11):2698–708.

    Article  PubMed  CAS  Google Scholar 

  7. Wheeler JE, et al. Lobular carcinoma in situ of the breast. Long-term followup. Cancer. 1974;34(3):554–63.

    Article  PubMed  CAS  Google Scholar 

  8. Rosen PP, et al. Lobular carcinoma in situ of the breast. Detailed analysis of 99 patients with average follow-up of 24 years. Am J Surg Pathol. 1978;2(3):225–51.

    Article  PubMed  CAS  Google Scholar 

  9. Georgian-Smith D, Lawton TJ. Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 2001;176(5):1255–9.

    PubMed  CAS  Google Scholar 

  10. Sneige N, et al. Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 2002;15(10):1044–50.

    Article  PubMed  Google Scholar 

  11. Fadare O, et al. Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: a clinicopathologic study of 18 cases. Am J Surg Pathol. 2006;30(11):1445–53.

    Article  PubMed  Google Scholar 

  12. Schnitt SJ, Vincent-Salomon A. Columnar cell lesions of the breast. Adv Anat Pathol. 2003;10(3):113–24.

    Article  PubMed  Google Scholar 

  13. Moinfar F. Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance—it is time to appreciate the Azzopardi concept! Arch Pathol Lab Med. 2009;133(6):879–92.

    PubMed  Google Scholar 

  14. Tavassoli FA, et al. Intraductal proliferative lesions. In: Tavassoli FA, Devilee P, editors. World Health Organization Classification of Tumor of the Breast and Female Genital Organs. Lyon: IARC; 2003. p. 63–75.

    Google Scholar 

  15. Lerwill MF. Flat epithelial atypia of the breast. Arch Pathol Lab Med. 2008;132(4):615–21.

    PubMed  Google Scholar 

  16. Pinder SE, Ellis IO. The diagnosis and management of pre-invasive breast disease: ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH)—current definitions and classification. Breast Cancer Res. 2003;5(5):254–7.

    Article  PubMed  Google Scholar 

  17. Page DL, Rogers LW. Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia. Hum Pathol. 1992;23(10):1095–7.

    Article  PubMed  CAS  Google Scholar 

  18. Simpson JF. Update on atypical epithelial hyperplasia and ductal carcinoma in situ. Pathology. 2009;41(1):36–9.

    Article  PubMed  Google Scholar 

  19. Tavassoli FA. Intraductal hyperplasias, ordinary and atypical. In: Tavassoli FA, editor. Pathology of the breast. Norwalk: Appleton & Lange; 1992. p. 155–91.

    Google Scholar 

  20. Rosai J. Borderline epithelial lesions of the breast. Am J Surg Pathol. 1991;15(3):209–21.

    Article  PubMed  CAS  Google Scholar 

  21. Page DL, et al. Subsequent breast carcinoma risk after biopsy with atypia in a breast papilloma. Cancer. 1996;78(2):258–66.

    Article  PubMed  CAS  Google Scholar 

  22. Collins LC, Schnitt SJ. Papillary lesions of the breast: selected diagnostic and management issues. Histopathology. 2008;52(1):20–9.

    Article  PubMed  CAS  Google Scholar 

  23. Harjit K, et al. Multiple papillomas of the breast: is current management adequate? Breast. 2006;15(6):777–81.

    Article  PubMed  Google Scholar 

  24. Lewis JT, et al. An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. Am J Surg Pathol. 2006;30(6):665–72.

    Article  PubMed  Google Scholar 

  25. Page D, Anderson T. Radial scars and complex sclerosing lesions. In: Anderson T, editor. Diagnostic histopathology of the breast. Edinburgh: Churchill Livingston; 1987. p. 89–103.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pacific Breast Pathology Medical Corporation, 101 Calypso Shores, Novato, CA, 94949, USA

    Thomas J. Lawton M.D.

Authors
  1. Thomas J. Lawton M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas J. Lawton M.D. .

Editor information

Editors and Affiliations

  1. Feinberg School of Medicine, Division of Breast Surgery, Northwestern University, 250 E. Superior St., Prentice 4-420, Chicago, 60611, Illinois, USA

    Nora M. Hansen

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lawton, T.J. (2013). High Risk Breast Lesions and Pathologic Evaluation. In: Hansen, N. (eds) Management of the Patient at High Risk for Breast Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5891-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-5891-3_4

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-5890-6

  • Online ISBN: 978-1-4614-5891-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation