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The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting

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Cell Death Signaling in Cancer Biology and Treatment

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Autophagy is a cellular survival mechanism influenced by a wide variety of intracellular and extracellular stresses including energy and oxygen deprivation, signaling aberrancies, ER stress, DNA damage, systemic cancer therapies, and radiotherapies. There is growing evidence that it may potentiate cancer survival. A number of clinical trials have been launched using autophagy inhibition in combination with standard cancer therapeutics. The information gleaned from these as well as ongoing in vitro and in vivo studies will allow us to better understand the role of autophagy in cancer.

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  1. Abramson Cancer Center and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 16 Penn Tower, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Reshma Rangwala & Ravi Amaravadi

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  1. Reshma Rangwala
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  2. Ravi Amaravadi
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Correspondence to Ravi Amaravadi .

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  1. Department of Medicine, University of Pittsburgh Division of Hematology/Oncology, Pittsburgh, Pennsylvania, USA

    Daniel E. Johnson

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Rangwala, R., Amaravadi, R. (2013). The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting. In: Johnson, D. (eds) Cell Death Signaling in Cancer Biology and Treatment. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5847-0_4

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