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Harnessing Death Receptor Signaling for Cancer Treatment

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Cell Death Signaling in Cancer Biology and Treatment

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Apoptosis, the cell’s intrinsic cell death program, is a key regulator of tissue homeostasis. Accordingly, tilting the balance between cell death on one side and cell proliferation on the other side toward survival promotes tumor formation. The death receptor (extrinsic) pathway represents one of the major apoptosis signaling cascades, which links exogenous stimuli via transmembrane surface receptors to the intracellular signaling machinery that mediates and executes the death signal. Since defects in death receptor signaling can confer resistance to apoptosis, a better understanding of the regulation of the signaling events and their perturbation in human cancers may lead to the identification of new molecular targets that can be exploited for therapeutic purposes. This strategy is expected to open new perspectives to target the death receptor pathway for cancer therapy.

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Acknowledgments

Work in the author’s laboratory is supported by grants from the Deutsche Forschungsgemeinschaft, the Deutsche Krebshilfe, the Bundesministerium für Forschung und Technologie (01GM0871, 01GM1104C), Wilhelm-Sander-Stiftung, Else Kröner-Fresenius-Stiftung, Novartis Stiftung für therapeutische Forschung, the European Community (ApopTrain, APO-SYS), and IAP6/18.

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  1. Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany

    Simone Fulda

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  1. Department of Medicine, University of Pittsburgh Division of Hematology/Oncology, Pittsburgh, Pennsylvania, USA

    Daniel E. Johnson

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Fulda, S. (2013). Harnessing Death Receptor Signaling for Cancer Treatment. In: Johnson, D. (eds) Cell Death Signaling in Cancer Biology and Treatment. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5847-0_11

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