Abstract
Acupuncture analgesia has been a common modality for management of acute and chronic pain. Acupuncture analgesia was based on the traditional Chinese medicine theory of the balance of Yin and Yang to regulate the Qi (energy) and blood. The Qi travels through various channels in the body via meridians. Although it is difficult to translate and poorly understood in Western scientific terms, both basic and clinical research on acupuncture analgesia has begun to expose substantial progress. There are correlations between acupuncture analgesia and the neural pathways such as afferent peripheral transduction and nerve transmission, ascending and descending modulation pathways, interpretation and central processing in the brain. Ongoing animal study models have yielded insight into acupuncture analgesia starting from behavioral observation and then dissect into the molecular level. Newer imaging techniques, e.g., functional magnetic resonance imaging (FMRI) and positron emission tomography (PET) scan have gradually revealed varying levels of neural modulation throughout central nervous system. Despite the deficiency of a vibrant consensus exploring the mechanism of its effect on analgesia, acupuncture has been shown to be beneficial in management of acute and chronic pain. Basic and clinical research has explored and compared electroacupuncture to manual acupuncture. There were greater analgesia and less intense pain during a brief period of electrical stimulation versus manual acupuncture. The clinical assessment and application of diverse frequencies and duration of electroacupuncture versus manual acupuncture may provide effective and systematic benefit. Further ongoing research is still in great demand in order to better elucidate the mechanism of acupuncture analgesia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Astin JA, Marie A, Pelletier KR, Hansen E, Haskell WL. A review of the incorporation of complementary and alternative medicine by mainstream physicians. Arch Intern Med. 1998;158:2303–10.
NIH Consensus Conference. Acupuncture. JAMA 1998;280:1518–24.
Research Group of Acupuncture Anesthesia PMC. The effect of acupuncture on human skin pain threshold. Chin Med J. 1973;3:151–7.
Lim T, Loh T, Kranz H, Scott D. Acupuncture—effect on normal subjects. Med J Aust. 1977;1:440–2.
Zhou PH, Qian PD, Huang DK, Gu HY, Wang HR. A study of the relationships between the points of the channels and peripheral nerves. National Symposia of Acupuncture-Moxibustion & Acupucture Anesthesia, Beijing; 1972. p. 302.
Han JS, Zhou Z, Xuan Y. Acupuncture has an analgesic effect in rabbits. Pain. 1983;15:83–91.
Chiang CY, Chang CT, Chu HC, Yang LF. Peripheral afferent pathway for acupuncture analgesia. Sci Sin. 1973;16:210–7.
Shen E, Wu WY, Du HJ, Wei JY, Zhu DX. Electromyographic activity produced locally by acupuncture manipulation. Chin Med J. 1973;9:532–5.
Zhang D, Ding GH, Shen ZY, Yao W, Zhang ZY, Zhang YQ, Lin JY. Influence of mast cell function on the analgesic effect o acupuncture of “Zusanli” (ST 36) in rats. Acupunct Res. 2007;31:147–52.
Yu X, Ding G, Huang H, Lin J, Yao W, Zhan R. Role of collagen fibers in acupuncture analgesia therapy on rats. Connect Tissue Res. 2009;50:110–20.
Chiang CY, Liu JY, Chu TH, Pai YH, Chang SC. Studies of spinal ascending pathway for acupuncture analgesia. Sci Sin. 1975;18:651–8.
Pan B, Castro-Lopes J, Coimbra A. Chemical sensory deafferentation abolishes hypothalamo-pituitary activation induced by noxious stimulation or electroacupuncture but only decreases that caused by immobilization stress. A c-fos study. Neuroscience. 1997;78:1059–68.
Li AH, Zhang JM, Xie YK. Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings. Brain Res. 2004;1012:154–9.
Pomeranz B, Cheng R. Suppression of noxious responses in single neurons of cat spinal cord by electroacupuncture and its reversal by the opiate antagonist naloxone. Exp Neurol. 1979;64:327–41.
Chung JM, Fang ZR, Hori Y, Lee KH, Willis WD. Prolonged inhibition of primate spinothalamic tract cells by peripheral nerve stimulation. Pain. 1984;19:259–75.
Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. The effect of ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. J Altern Complement Med. 2005;11:653–61.
Zhu LX, Li CY, Yang B, Ji CF, Li WM. The effect of neonatal capsaicin on acupuncture Analgesia. Acupunct Res. 1990;15:285–91.
Wei JY, Chang SC, Feng CC. Activation of unmyelinated muscle afferents by acupuncture or pressure exerted on muscle. Acta Zool Sin. 1978;24:21–8.
Liu X. The modulation of cerebral cortex and subcortical nuclei on NRM and their role in acupuncture analgesia. Zhn Ci Yan Jiu. 1996;21:4–11.
Liu GJ, Wang S. Effects of nucleus raphe magnus and locus coeroleus in descending modulation of habenula on pain threshold and acupuncture analgesia. Acta Pharmacol Sin. 1988;9:18–22.
Peets J, Pomeranz B. CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia. Nature. 1978;273:675–6.
Cheng RS, Pomeranz B. Electroacupuncture analgesia could be mediated by at least two pain-relieving mechanisms: endorphin and non-endorphin systems. Life Sci. 1979;25:1957–62.
Han J. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 2003;26:17–22.
Wang Y, Zhang Y, Wang W, Cao Y, Han JS. Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception. Exp Neurol. 2005;192:156–62.
Han JS, Terenius L. Neurochemical basis of AA. Annu Rev Pharmacol Toxicol. 1982;22:193–220.
Han JS. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 2003;26:17–22.
Huang C, Hu ZP, Long H, Shi YS, Han JS, Wan Y. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain. Brain Res Bull. 2004;63:99–103.
Huang C, Hua ZP, Jiang SZ, Li HT, Han JS, Wan Y. CCK-8 receptor antagonist L365, 260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice. Brain Res Bull. 2007;71:447–51.
Zhou Y, Sun YH, Shen JM, Han JS. Increased release of immunoreactive CCK-8 by electroacupuncture and enhancement of electroacupucture analgesia by CCK-B antagonist in rat spinal cord. Neuropeptides. 1993;24:139–44.
Dong XW, Jiang ZH. Acupuncture-induced analgesia and increase in monoamine fluorescence intensity in the rat nucleus raphe magnus. Acta Phiol Sin. 1981;33:24–9.
Chang FC, Tsai HY, Yu MC, Yi PL, Lin JG. The central serotonergic system mediates the analgesic effect of electroacupuncture on Zusanli (ST 36) acupoints. J Bioed Sci. 2004;11:179–85.
Sun RQ, Wang HC, Wan Y, Jing Z, Luo F, Hang JS, Wang Y. Suppression of neuropathic pain by peripheral electrical stimulation in rats: a-opioid receptor and NMDA receptor implicated. Exp Neurol. 2004;187:23–9.
Huang C, Li HT, Shi YS, Han JS, Wan Y. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain. Neurosci Lett. 2004;368:327–31.
Sun S, Chen WL, Wang PF, Zhao ZQ, Zhang YQ. Disruption of glial function enhances electroacupuncture analgesia in arthritic rats. Exp Neurol. 2006;198:294–302.
Kang JM, Park HJ, Choi YG, Choe IH, Park JH, Kim YS, Lim S. Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model. Brain Res. 2007;1131:211–9.
Lau WK, Lau YM, Zhang HQ, Wong SC, Bian ZX. Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model. Neuroscience. 2010 Oct 13;170(2):655–61.
He L. Involvement of endogenous opioid peptides in acupuncture analgesia. Pain. 1987;31:99–121.
Guo HF, Tian JH, Wang Y, Fang YP, Hou Y, Han JS. Brain substrates activated by electro acupuncture of different frequencies (I): comparative study on the expression of oncogen c-fos and genes coding for three opioid peptides. Mol Brain Res. 1996;43:157–66.
Pan B, Castro-Lopes J, Coimbra A. Activation of anterior lob corticotrophs by electroacupuncture or noxious stimulation in the anesthetized rate, as shown by colocalization of Fos protein with ACTH and beta-endorphin and increased hormone release. Brain Res Bull. 1996;40:175–82.
Pan B, Castro-Lopes J, Coimbra A. Chemical sensory deafferentation abolishes hypothalamic pituitary activation induced by noxious stimulation or electroacupuncture but only decreased that caused by immobilization stress. A c-fos study. Neuroscience. 1997;78:1059–68.
Lao L, Zhang RX, Zhang G, Wang X, Berman BM, Ren K. A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Res. 2004;1020:18–29.
Melzack R, Wall P. Pain mechanisms: a new theory. Science. 1965;150(3699);971–79.
Liu WC, Feldman SC, Cook DB, Hung DL, Xu T, Kalnin AJ, Komisaruk BR. fMRI study of acupuncture-induced periaqueductal gray activity in humans. Neuroreport. 2004;15:1937–40.
Hui KK, Liu J, Makris N, Gollub RL, Chen AJ, Moore CI, Kennedy DN, Rosen BR, Kwong KK. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp. 2000;9:13–25.
Chiu JH, Chung MS, Cheng HC, Yeh TC, Hsieh JC, Chang CY, Kuo WY, Cheng H, Ho LT. Different central manifestations in response to electroacupuncture at analgesic and nonanalgesic acupoints in rats: a manganese-enhanced functional magnetic resonance imaging study. Can J Vet Res. 2003;67:94–101.
Hui KK, Liu J, Marina O, Napadow V, Haselgrove C, Kwong KK, Kennedy DN, Makris N. The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST36 as evidenced by fMRI. Neuroimage. 2005;27:479–96.
Zhang W, Jin Z, Huang J, Zhang YW, Luo F, Chen AC, Han JS. Modulation of cold pain in human brain by electric acupoint stimulation: evidence from fMRI. Neuroreport. 2003;14:1591–6.
Liu P, Zhou G, Zhang Y, Dong M, Qin W, Yan K, Sun J, Liu J, Liang J, Deneen KM von, Liu Y, Tain J. The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST 36: an fMRI study. Neurosci Let. 2010;479:267–71.
Wang SM, Constable RT, Tokoglu FS, Weiss DA, Freyle D, Kain ZN. Acupuncture-induced blood oxygenation level-dependent signals in awake and anesthetized volunteers: a pilot study. Anesth Analg. 2007;105:490–506.
Napadow V, Dhond RP, Kim J, LaCount L, Vangel M, Harris RE, Kettner N, Park K. Brain encoding of acupuncture sensation—coupling on-line rating with fMRI. Neuroimage. 2009;47(3):1055–65.
Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opiod receptors (MORs). Neuroimage. 2009;47(3):1077–85.
An YS, Moon SK, Min IK, Kim DY. Changes in regional cerebral blood flow and glucose metabolism following electroacupuncture at LI 4 and LI 11 in normal volunteers. L Altern Complement Med. 2009;15(10):1075–81.
Park MS, Sunwoo YY, Jang KS, Han YM, Kim MW, Maeng LS, Hong YP OJH, Chung YA. Changes in brain FDG metabolism induced by acupuncture in healthy volunteers. Acta Radiol. 2010;51(8):947–52.
Lang PM, Stoer J, Schober GM, Audette JF, Irnich D. Bilateral acupuncture analgesia observed by quantitative sensory testing in healthy volunteers. Anesth Analg. 2010 May 1;110(5):1448–56.
Schliessbach J, Klift E van der, Arendt-Nielsen L, Curatolo M, Streitberger K. The effect of brief electrical and manual acupuncture stimulation on mechanical experimental pain. Pain Med. 2011 Feb;12(2):268–75.
Zhou W, Liang-Wu F, Tjen-A-Looi SC, Li P, Longhurst JC. Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses. J Appl Physiol. 2005;98:872–80.
Wang SM, Lin EC, Maranets I, Kain ZN. The impact of asynchronous electroacupuncture stimulation duration on cold thermal pain threshold. Anes Analg. 2009;109(3):932–5.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lee, A., Hsu, EZ. (2014). Mechanisms of Acupuncture Analgesia. In: Lin, YC., Hsu, EZ. (eds) Acupuncture for Pain Management. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5275-1_4
Download citation
DOI: https://doi.org/10.1007/978-1-4614-5275-1_4
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-5274-4
Online ISBN: 978-1-4614-5275-1
eBook Packages: MedicineMedicine (R0)