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Introduction

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Application of Peptide-Based Prodrug Chemistry in Drug Development

Part of the book series: SpringerBriefs in Pharmaceutical Science & Drug Development ((BRIEFSPSDD))

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Abstract

This chapter introduces diabetes, an ancient disease that continues to affect diverse populations in modern times and the various types of diabetes are discussed. Insulin has been traditionally used to treat the disease. However, the one significant limitation of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia. Glucagon-like Peptide-1 (GLP1) is a 30 amino acid peptide that stimulates insulin only when the blood glucose level is high, hence the risk of hypoglycemia is substantially minimized. However, the biggest problem in the therapeutic use of GLP-1 is its extremely short half-life in plasma (~2 min). In the last subsection of this chapter, the utility of prodrugs is discussed in general and how GLP-1 based prodrugs could appropriately extend the biological half life and broaden the therapeutic index of GLP.

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Authors and Affiliations

  1. Hammer Health Sciences Center 1208, Department of Microbiology, Columbia University Medical Center, W. 168 Street 701, New York, 10032, NY, USA

    Arnab De

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  1. Arnab De
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Correspondence to Arnab De .

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De, A. (2013). Introduction. In: Application of Peptide-Based Prodrug Chemistry in Drug Development. SpringerBriefs in Pharmaceutical Science & Drug Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4875-4_1

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  • DOI: https://doi.org/10.1007/978-1-4614-4875-4_1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4874-7

  • Online ISBN: 978-1-4614-4875-4

  • eBook Packages: MedicineMedicine (R0)

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