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Analytical Considerations for Microdialysis Sampling

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Microdialysis in Drug Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

Abstract

In this chapter, a wide variety of analytical techniques that can be used in combination with microdialysis sampling will be described. Most of these methods are also commonly used for other biological samples, such as blood, urine, and tissues. However, when using microdialysis, the analysis and sampling must be viewed as a unified experiment where a parameter directly affecting one aspect will indirectly affect all the other components of the experiment. It is therefore almost never appropriate to simply apply an analytical method developed for a different sampling system to microdialysis sampling. The analyst must develop a method with the recognition of the small sample volumes available, the difficulty in sample preconcentration, and the high ionic strength of the matrix. Therefore, the discussion will focus on the particular developments needed to most appropriately apply various analytical methods to microdialysis sampling.

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Authors and Affiliations

  1. Ralph N. Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Lawrence, KS, USA

    Justin C. Cooley, Anne R. Regel & Craig E. Lunte

  2. Ralph N. Adams Institute for Bioanalytical Chemistry and Department of Chemistry, Missouri Western State University, St. Joseph, MO, USA

    Michael W. Ducey

  3. Department of Pharmaceutical Chemistry and Ralph N. Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Lawrence, KS, USA

    Susan M. Lunte

  4. Department of Pharmaceutical Chemistry and Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS, USA

    Pradyot Nandi

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  1. Justin C. Cooley
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  2. Michael W. Ducey
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  3. Anne R. Regel
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  5. Susan M. Lunte
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Correspondence to Craig E. Lunte .

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  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Cooley, J.C., Ducey, M.W., Regel, A.R., Nandi, P., Lunte, S.M., Lunte, C.E. (2013). Analytical Considerations for Microdialysis Sampling. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_3

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